Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2005-10-24
2009-11-03
Truong, Duc (Department: 1796)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S482000, C549S352000, C549S223000, C549S482000, C548S518000, C548S473000, C546S255000, C562S498000, C556S449000
Reexamination Certificate
active
07612153
ABSTRACT:
The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
REFERENCES:
patent: 5455027 (1995-10-01), Zalipsky et al.
patent: 5686110 (1997-11-01), Greenwald et al.
patent: 5756593 (1998-05-01), Martinez et al.
patent: 5808096 (1998-09-01), Zalipsky
patent: 5824701 (1998-10-01), Greenwald et al.
patent: 6127355 (2000-10-01), Greenwald et al.
patent: 6180095 (2001-01-01), Greenwald et al.
patent: 6251382 (2001-06-01), Greenwald et al.
patent: 6448369 (2002-09-01), Bentley et al.
patent: 6608076 (2003-08-01), Greenwald et al.
patent: 6649778 (2003-11-01), Zhao et al.
patent: 6703446 (2004-03-01), Schwindeman et al.
patent: 6720391 (2004-04-01), Schwindeman et al.
patent: 6737505 (2004-05-01), Bentley et al.
patent: 6777387 (2004-08-01), Greenwald et al.
patent: 6894025 (2005-05-01), Harris
patent: 6899867 (2005-05-01), Bentley et al.
patent: 7026440 (2006-04-01), Bentley et al.
patent: 7033583 (2006-04-01), Choe et al.
patent: 2004/0116649 (2004-06-01), Kozlowski
patent: 2005/0031576 (2005-02-01), McManus et al.
patent: 2005/0036978 (2005-02-01), Kozlowski
patent: 2005/0054816 (2005-03-01), McManus et al.
patent: 2005/0119193 (2005-06-01), Motoyama
patent: 2005/0214250 (2005-09-01), Harris et al.
patent: 2008/0280998 (2008-11-01), Bonora et al.
patent: WO 2005/033181 (2005-04-01), None
Yoon et al; The photochemistry—biradical intermediates; Amercian Chemical society (2004), 126(4), 1110-1124; Chem Abstract 140: 217172.
Kikuchi et al; Preparation of pyrimidine—accelerators; Nishhin Flour Milling Co., Ltd., Japan; 1996, Chem Abstract 124: 232479.
Vidaluc et al; Flexible—evaluation; Amercian Chemical society; (1995), 38(15), 2969-73; Chem Abstract 123: 111638.
Akiyama et al; N-hydroxy amides—oligo(ethyleneoxy)arms; Physical organic Chemistry (1972-1999) (1989), (9), 1213-18, Chem Abstract 112:178261.
Clinton et al; Sulfur containing amines; Journal of the Amercian Chemical society; (1948), 70, 950-5, VChem Abstract 42: 27477.
Akiyama, et al., “Selective Synthesis Of Heterobifunctional Poly(ethylene glycol) Derivatives Containing Both Mercapto and Acetal Terminals.”,Bioconjugate Chem. 11: 947-950, 2000.
Akiyama, et al., “Synthesis Of Heterotelechelic Poly(ethylene glycol) Derivatives Having α-Benzaldehyde And ω-Pyridyl Disulfide Groups By Ring Opening Polymerization Of Ethylene Oxide Using 4-(Diethoxymethyl)benzyl Alkoxide As A Novel Initiator.”,Bioconjugate Chem. 15: 424-427, 2004.
Akiyama, et al., “Synthesis Of Poly(ethylene glycol)-Block-Poly(ethylenimine) Possessing An Acetal Group At The PEG End.”,Macromolecules33: 5841-5845, 2000.
Bettinger, et al., “Convenient Polymer-Supported Synthetic Route To Heterobifunctional Polyethylene Glycols.”,Bioconjugate Chem. 9: 842-846, 1998.
Cammas, et al., “Heterobifunctional Poly(ethylene Oxide): Synthesis Of α-Hydroxy-ω-Amino PEOs With The Same Molecular Weights.”,Bioconjugate Chem. 6: 226-230, 1995.
Dombi, et al., “Oligonucleotide Arrays From Aldehyde-Bearing Glass With Coated Background.”,Synthesis6: 816-824, 2002.
Glaied, et al., “Oxazoline-Terminated Macromonomers By The Alkylation Of 2-Methy1-2-Oxazoline.”,Journal of Polymer Science: Part A: Polymer Chem. 43: 2440-2447, 2005.
Heroguez, et al., “Synthesis Of α-Norbornenylpoly(ethylene oxide) Macromonomers And Their Ring-Opening Metathesis Polymerization.”,Macromolecules29(13): 4459-4464, 1996.
Huang, et al., “The Kinetics Of The Attachment Of Polymer Chains To Reactive Latex Particles And The Resulting Latex Stabilization,”J. of Polymer Sci., 23: 795-799, 1985.
Kazanskii, et al., “Strictly Monofunctional Methyl Ethers Of Poly(ethylene glycol) And The Related Methacrylate Macromonomers.”,Polymer Science Ser. A. 42(6): 585-595, 2000.
Kim, et al., “Heterobifunctional Poly(ethylene oxide),”Polymer Bulletin, 33: 1-6, 1994.
Li and Kao, “Synthesis Of Polyethylene Glycol (PEG) Derivatives And PEGylated-Peptide Biopolymer Conjugates.”,Biomacromolecules4: 1055-1067, 2003.
Link, et al., “Presentation And Detection Of Azide Functionality In Bacterial Cell Surface Proteins.”,J. Am. Chem. Soc. XXXX(XXX): A-E.
Mongondry, et al., “Mild Synthesis Of Amino-Poly(ethylene glycol)s. Application To Steric Stabilization Of Clays.”,Macromol. Rapid Commun. 24: 681-685, 2003.
Nagasaki, et al., “Primary Amino-Terminal Heterobifunctional Poly(ethylene Oxide). Facile Synthesis of Poly(ethylene Oxide) With A Primary Amino Group At One End And A Hydroxyl Group At The Other End.”,Bioconjugate Chem. 6: 702-704, 1995.
Nagasaki, et al., “Synthesis Of Heterotelechelic Poly(ethylene glycol) Macromonomers. Preparation Of Poly(ethylene glycol) Possessing A Methacryloyl Group At One End And A Formyl Group At The Other End.”,Macromolecules30: 6489-6493, 1997.
Nakamura, et al., “Synthesis of Heterobifunctional Poly(ethylene glycol) With A Reducing Monosaccharide Residue At One End.”,Bioconjugate Chem. 9: 300-303, 1998.
Parrish, et al., “Bio-Tailored Amphiphilic Graft Copolymers.”,Polymer Preprints46(1): 126, 2005.
Parrish, et al., “PEG- And Peptide-Grafted Aliphatic Polyesters By Click Chemistry.”,J. Am. Chem. Soc. 127(20): 7404-7410, 2005.
Parrish, et al., “PEG- And Peptide-Tailored Aliphatic Polyesters Synthesized By ‘Click’ Cycloaddition Chemistry.”,Polymer Preprints46(1): 292-293, 2005.
Reed and Janda, “A One-Step Synthesis Of Monoprotected Polyethylene Glycol Ethers,”J. Org. Chem., 65: 5843-5845, 2000.
Ryoo, et al., “Efficient Methods Of Converting Hydroxyl Groups Into Amino Groups In Poly(ethylene glycol)-Grafted Polystyrene Resin.”,Journal of Combinatorial Chem. 4(3): 187-190, 2002.
Senyo, et al., “Syntheses of Poly(ethylene oxide) Macromonomers Carrying Tertiary Amine And Quaternary Ammonium End Groups.”,Polymer Journal35(6): 513-518, 2003.
Shen, et al., “One-Step Synthesis of α-p-Vinylphenylalkyl-ω-Hydroxy Poly(ethylene Oxide) Macromonomers By Anionic Polymerization Initiated From p-Vinylphenylalkanols.”,Polymer44: 3221-3228, 2003.
Zhang, et al., “Synthesis Of Heterobifunctional Poly(ethylene glycol) With A Primary Amino Group At One End And A Carboxylate Group At The Other End.”,Reactive&Functional Polymers56: 17-25, 2003.
Breitenkamp Kurt
Sill Kevin
Skaff Habib
Choate Hall & Stewart LLP
Intezyne Technologies, Inc.
Robidoux Andrea L. C.
Truong Duc
LandOfFree
Heterobifunctional poly(ethylene glycol) and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterobifunctional poly(ethylene glycol) and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterobifunctional poly(ethylene glycol) and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4096926