Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1996-02-22
1999-12-21
Isabella, David J.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 6, A61F 202, A61F 214
Patent
active
060051604
ABSTRACT:
This invention is a heterobifunctional artificial cornea or biomedical membrane and novel process for preparing the heterobifunctional artificial cornea. In this method, plasma induced graft polymerization is adopted to provide the surface property modification of polymer materials like silicone or polyurethane. At first, the frontal side of the material is grafted with polyacrylic acid or polymethacrylic acid and then bonded with collagen, or 2-hydroxyethylmethacrylate (HEMA) is grafted alone. A surface which increases the cell attachment and growth can be then developed. Another side of this membrane is grafted with acrylic acid or polymethacrylic acid and then different molecular weights of polyethylene oxide (PEO) is bonded thereto. 2-methacryloyl-oxyethyl phosphoryl chloride (2-MPC) is grafted to the membrane. The copolymer of the 2-methacryl-oyloxyethyl phosphoryl chloride and MPC-co-butyl methacrylate can be used in preparing a special surface which can inhibit the attachments of cells and protein molecules. Thus, a heterobi-functional biomedical membrane can be developed. In this work, the surface characterization of this membrane, in vitro study and animal in vivo study are also investigated. The obtained results exhibit a very good performance. Moreover, it demonstrates that the developed product has good transparency, hydrophilicity and high biocompatibility, thereby exhibiting the high potential in the application field of artificial cornea.
REFERENCES:
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patent: 5376400 (1994-12-01), Goldberg et al.
Girard, et al., Keratoprosthesis: A 12-Year Follow-Up, Transactions-American Academy of Ophthalmology & Otolaryngology, 83(2), 252-267, 1977.
Cardona, Mushroom Transcorneal Keratoprosthesis, American J. Ophthal, 68, No. 4, 604-612, 1969.
Kirkham, et al., The Keratoprosthesis: Improved Biocompatability Through Design and Surface Modification, Ophthalmic Surgery, 22, No. 8, 455-461, 1991.
Kobayashi, et al., Collagen-Immobilized Hydrogel as a Material for Lamellar Keratoplasty, J. Applied Biomaterial, 2, 261-267, 1991.
Chung Patricia Chuen-Tsuei
Hsiue Ging-Ho
Lee Shyh-Dar
Black John M.
Isabella David J.
National Science Council
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