Heterobifunctional linking agents derived from N-succinimido-dit

Details Heterobifunctional linking agents derived from N-succinimido-dit Heterobifunctional linking agents derived from N-succinimido-dit

1987-08-27

1989-11-14

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548542, C07D20746, C07D20748, C07D40112

Patent

active

048809357

ABSTRACT:
The efficacy of immunotoxins having an antibody that recognizes a tumour associated antigen linked to a cytotoxin through a heterobifunctional agent of the disulphide type is improved by providing in the heterobifunctional agent a molecular grouping creating steric hindrance in relation to the disulphide link. This steric hindrance can be provided by a methyl substituted methylene group located in the heterobifunctional link adjacent to the disulphide bond.

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