Heterobifunctional antibodies having dual specificity for fibrin

Details Heterobifunctional antibodies having dual specificity for fibrin Heterobifunctional antibodies having dual specificity for fibrin

1992-10-13

1995-09-26

Lacey, David L.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

5303873, 53038825, 53038826, 5303893, 435 7021, 4351722, 43524027, 935104, 935107, 4241461, 4241581, A61K 39395, C07K 1528

Patent

active

054532698

ABSTRACT:
Heterobifunctional antibodies having dual specificities, one specificity directed against a thrombus, and the other specificity directed against a thrombolytic agent are disclosed. The invention also relates to methods of using these heterobifunctional antibodies to lyse a thrombus.

REFERENCES:
patent: 4273873 (1981-06-01), Sugitachi et al.
patent: 4470925 (1984-09-01), Auditore-Hargreaves
patent: 4474893 (1984-10-01), Reading
patent: 4833085 (1989-05-01), Schaumann et al.
Agnelli et al., Circulation 72(1):178-182 (1985).
Agnelli et al., Thrombosis and Haemostasis 63(2):204-207 (1990).
Agnelli et al., Blood 66(2):399-401 (1985).
Collen et al., Circulation 74(4):838-842 (1986).
Collen et al., Circulation 84(3):1216-1234 (1991).
Emeis et al., Arzneimittelforschung 42(3):358-362 (1992).
Gardell et al., Circulation 84(1):244-253 (1991).
Larsen et al., The Journal of Biological Chemistry 266(13):8156-8161 (1991).
Lijnen et al., The Journal of Biological Chemistry 263(12):5594-5598 (1988).
Lijnen et al., Thrombosis and Haemostasis 66(4):468-473 (1991).
Martin et al., Z. Kardiol. 79:Suppl 3, 167-170 (1990).
Matsuo et al., Thrombosis Research 42:187-194 (1986).
Sobel et al., Circulation 81(4):1362-1373 (1990).
Stump et al., Blood 69(2):592-596 (1987).
Branscomb et al., Thrombosis and Haemostasis 64:260-266 (1990).
Branscomb, E. E. et al., Thromb. Haemost. 64:260 (1990).
Bode, C. et al., Circulation 81:1974 (1990).
Charpie, J. R. et al., Biochemistry 29:6374 (1990).
Bode, C. et al., J. Biol. Chem. 264:944 (1989).
Runge, M. S. et al., Clin. Res. 36:501 (1988).
Runge, M. S. et al., Trans. Assoc. Am. Phys. 100:250 (1987).
Runge, M. S. et al., Biochemistry 27:1153 (1988).
Runge, M. S. et al., Proc. Natl. Acad. Sci., USA 84:7659 (1987).
Bode, C. et al., J. Mol. Cell Cardiol. 19:335 (1987).
Bode, C. et al., Science 229:765 (1985).
Sevilla, C. L. et al., Biochem. Biophys. Res. Commun. 130:91 (1985).
Duberstein, R., Genetic Engineering News 6:22 (1986).
Lanzavecchia A. et al., Eur. J. Immunol. 17:105 (1987).
Staerz, U. D. et al., Proc. Natl. Acad. Sci. USA 83:1453 (1986).
Milstein, C. et al., Nature 305:537 (1983).
Liu, M. A. et al., Proc. Natl. Acad. Sci. USA 82:8648 (1985).
Brennan, M. et al., Science 229:81 (1985).
Nisonoff, A. et al., Nature 194:355 (1962).
Kudryk, B. et al., Molec. Immunol. 21:89 (1984).
Hui, K. Y. et al., Science 222:1129 (1983).
Kato, K. et al., Chem. Abstr. 94:325, Abstract No. 61048j (1981).
Angles-Cano, E. R., Chem. Abstr. 104:307, Abstract No. 144639d (1986).
International Search Report for PCT/US87/00860.
Waldman, T. A., "Monocloral Antibodies in Diagnosis and Therapy," Science 252:1657-1662, 21 Jun. 1991.
Liu et al., "Hetemantibodys Duplexes Target Cells for Lysis by Cytotoxic T Lymphocytes", Proc. Natl. Acad. Sci. USA 82:8648-8652, Dec. 1985.
Hui et al., "Monoclonal Antibodies to a Synthetic Fibrin-Like Peptide Bind to Human Fibrin but not Fibringen," Science 222:1129-1131, 9 Dec. 1983.
Milstein et al., "Hybrid Hybridomas and Their Use in Immunohistochemistry," Nature 305:537-540, Oct. 1983.

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