Heteroatoms-containing tricyclic compounds

Details Heteroatoms-containing tricyclic compounds Heteroatoms-containing tricyclic compounds

1991-05-09

1994-10-04

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514321, 514291, 540452, 540456, A61K 31695, A61K 31395, C07D49816

Patent

active

053526716

ABSTRACT:
The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with an acid having a non-nucleophilic anion, treatment with dimethylsulfoxide and acetic anhydride, acylation, treatment with an oxalyl derivative and ammonia, methylation, oxidation, deprotection and protection.
They possess interesting pharmacological activity as antiinflammatory, immunosuppressant, antiproliferative and chemotherapeutic drug resistance reversing agents.

REFERENCES:
patent: 5143918 (1992-09-01), Bochis et al.
patent: 5162334 (1992-11-01), Goulet et al.
patent: 5189842 (1993-02-01), Goulet et al.
patent: 5208228 (1993-05-01), Ok et al.
J. Am. Chem. Soc. 1987, 109, 5031-5033, Tenaka, et al.

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