Heteroatomic oligonucleoside linkages

Details Heteroatomic oligonucleoside linkages Heteroatomic oligonucleoside linkages

1997-02-04

1998-07-07

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, 514 44, C07H 2100, C07H 2102, C07H 2104, A61K 3170

Patent

active

057770921

ABSTRACT:
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.

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