Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis

Details Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis

1992-08-27

1994-05-03

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514338, 514365, 514444, 514450, 514451, 514460, 546270, 546283, 546284, 546268, 548203, 549 60, 549355, 549414, 549420, 549423, A61K 31445, A61K 31335, C07D30910, C07D30902

Patent

active

053088522

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4486445 (1984-12-01), Patel et al.
patent: 4937373 (1990-06-01), Carson et al.
The Merck Index, 11th ed., 5154, pp. 829 (1989).

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