Heteroarylheteroalkylamine derivatives and their use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S288000

Reexamination Certificate

active

07119109

ABSTRACT:
There are provided novel compounds of formula (I)wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease, CNS disorders and pain.

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Exp. Opin. Ther. Patents (2000) 10 (1) :125-129.
Guslandi, M. “Nitric Oxide and inflammatory bowel diseases”, European Journal of Clinical Investigation (1998), 28, 904-907.
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STN International, file Caplus, Caplus accession No. 1977:189458, document No. 86:189458, Rohto Pharmaceuticals Co., Ltd.: “Aromatic amino ether quaternary ammonium salts”; JP, B4, 51044934; 19761201.

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