Heteroaryl-substituted pyrrole derivatives, their...

Details Heteroaryl-substituted pyrrole derivatives, their... Heteroaryl-substituted pyrrole derivatives, their...

2006-10-17

2006-10-17

Jiang, Shaojia A. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S295000, C544S333000, C546S193000, C546S269700, C546S271400, C546S272700, C546S276400

Reexamination Certificate

active

07122666

ABSTRACT:
Compounds having activity against production of an inflammatory cytokine of formula (I)′:A′ is pyrrole; R1′is phenyl or naphthyl; R2′is pyridyl or pyrimidinyl; R3′is (IIa)′, (IIb)′ or (IIc)′:m′ is 1; E′ is nitrogen; D′ is >C(R5′)—, R5′is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; R4′is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′and R3′are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′and Rb′are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′and Rb′with the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′ is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.

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