Heteroaryl-substituted arylaminopyridine derivatives as MEK...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S269700, C546S275400

Reexamination Certificate

active

08076486

ABSTRACT:
The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia)Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

REFERENCES:
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patent: WO 2006045514 (2006-04-01), None
patent: WO 2006/045514 (2006-05-01), None
Chang, et al., “Signal Transduction Mediated by the Ras/Raf/MEK/ERK pathway from Cytokine Receptors to Transcription Factors: Potential Targeting for Therapeutic Intervention,”MTT Leukemia, 17:1263-1293 (2003).
Crews, et al., “The Primary Structure of MEK, a Protein Kinase That Phosphorylates the ERK Gene Product,”Science, 258:478-480 (1992).
Lee, et al., “Regulation of Hepatocyte Growth Factor-Mediated Urokinase Plasminogen Activator Secretion by MEK/ERK Activation in Human Stomach Cancer Cell Lines,”Experimental and Molecular Medicine, 38:27-35 (2006).
Reddy, el al., “Role of MAP Kinase in Tumor Progression and Invasion,”Cancer and Metastasis Reviews, 22:395-403 (2003).

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