Heteroaryl peptidomimetics as thrombin receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S331000

Reexamination Certificate

active

07618945

ABSTRACT:
The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

REFERENCES:
patent: 6365617 (2002-04-01), McComsey et al.
patent: 6858577 (2005-02-01), Zhang et al.
patent: 7183252 (2007-02-01), Zhang et al.
patent: 2002/0103138 (2002-08-01), D'Andrea et al.
patent: 2003/0224999 (2003-12-01), Zhang et al.
patent: 2004/0063642 (2004-04-01), Zhang et al.
patent: 2004/0138141 (2004-07-01), Zhang et al.
patent: WO 01/00576 (2001-01-01), None
patent: WO 01/00656 (2001-01-01), None
patent: WO 01/00657 (2001-01-01), None
patent: WO 01/00659 (2001-01-01), None
Andrade-Gordon, et al., “Design Synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor,” Proceedings of the National Academy of Science, 96(22): 12257-12262 (1999).
Vu, et al., Cell, 64: 1057-1068 (1991).
Nystedt, et al., Proceedings of the National Academy of Science, 91: 9208-9212 (1994).
Ishihara, et al., Nature, 386: 502-502 (1997).
Xu, et al., Proceedings of the National Academy of Science, 95: 6642-6646 (1998).
Cook, et al., Circulation, 91: 2961-2971 (1995).
Sugama, et al., Journal of Cell Biology, 119: 935-944 (1992).
Hung, et al., Journal of Cell Biology, 116: 827-832 (1992).
Tatakis, et al., Biochemical and Biophysical Research Communication, 174: 181-184 (1991).
Jalink, et al., Journal of Cell Biology, 118: 411-419 (1992).
Zhang, et al., Bioorganic Medicine Chemistry Letters, 11: 2105-2109 (2001).
Zhang, et al., Journal of Medical Chemistry, 44: 1021-1024 (2001).
Buchi, et al., Journal of American Chemical Society, 198: 4115-4119 (1986).
Jones, et al., Biochim. Biophys. Acta., 1136: 272-282 (1992).
PCT Search Report from International Application No. PCT/US03/39091 and dated Jul. 30, 2004.
Cabrera et al. Dynamic ordering of aggregated mesomorphic macromolecules Nature (London, United Kingdom) 1987, vol. 326, No. 6113, pp. 582-585.

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