Heteroaryl peptidomimetics as thrombin receptor antagonists

Details Heteroaryl peptidomimetics as thrombin receptor antagonists Heteroaryl peptidomimetics as thrombin receptor antagonists

2003-12-10

2009-12-08

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S019300, C530S331000, C548S304700, C548S361100

Reexamination Certificate

active

07629319

ABSTRACT:
The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

REFERENCES:
patent: 6365617 (2002-04-01), McComsey et al.
patent: 2002/0103138 (2002-08-01), D'Andrea et al.
patent: 2003/0224999 (2003-12-01), Zhang et al.
patent: 2004/0063642 (2004-04-01), Zhang et al.
patent: 2004/0138141 (2004-07-01), Zhang et al.
patent: WO 01/00576 (2001-01-01), None
patent: WO 01/00656 (2001-01-01), None
patent: WO 01/00657 (2001-01-01), None
patent: WO 01/00659 (2001-01-01), None
Cabrera et al. Dynamic ordering of aggregated mesomorphic macromolecules. Nature (London, United Kingdom) 1987, vol. 326, No. 6113, pp. 582-5.
T.-K. Vu,Cell1991, 64, 1057-1068.
S. Nystedt,Proc. Natl. Acad. Sci USA1994, 91, 9208-9212.
H. Ishihara,Nature1997, 386, 502-506.
W.-F. Xu,Proc. Natl. Acad. Sci USA1998, 95, 6642-6646.
J. J. CookCirculation1995, 91, 2961-2971.
Y. Sugama, J. Cell Biol. 1992, 119, 935-944.
D. T. Hung,J. Cell Biol.1992, 116, 827-832.
D. N. Tatakis,Biochem. Biophys. Res. Commun.1991, 174, 181-184.
K. Jalink,J. Cell. Biol.1992, 118, 411-419.
Zhang, H-C et. al.Bioorg. Med. Chem. Lett.2001, 11, 2105-2109.
Zhang, H-C et. al.J. Med. Chem.2001, 44, 1021-1024.
G. Buchi,J. Am. Chem. Soc.1986, 108, 4115-4119.
Jones,Biochim. Biophys. Acta1992, 1136, 272-282.
Andrade-Gordon, P. et al., “Design Synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor”, Proceedings of the National Academy of Science, Washington, US, vol. 96, No. 22, Oct. 1999, pp. 12257-12262.
PCT International Search Report, dated Jul. 30, 2004, for PCT Int'l. Appln. No. PCT/US03/39091.

Affiliated with

Also associated with

Rating

Heteroaryl peptidomimetics as thrombin receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heteroaryl peptidomimetics as thrombin receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroaryl peptidomimetics as thrombin receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4085754