Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-12-06
2008-03-25
Seaman, Margaret D. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S250000, C514S258100, C514S303000, C544S224000, C544S350000, C544S236000, C546S118000
Reexamination Certificate
active
07348326
ABSTRACT:
Disclosed are compounds of the formula:or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs, and enhancement of memory and alertness.
REFERENCES:
patent: 5527819 (1996-06-01), Williams et al.
patent: 6380210 (2002-04-01), DeSimone et al.
patent: 6972293 (2005-12-01), DeSimone et al.
Tanay et al., Neuropharmacology, “Chronic administration of antipanic drugs alters rat brainstem GABAa receptor subunit mRNA levels”, 1996, vol. 35, pp. 1475-1482.
Uzunova et al., Proceedings of the national academy of sciences of the united states of america, “Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine”, 1998, vol. 95, pp. 3239-3244.
DeSimone Robert
Hutchison Alan
Rosewater Daniel
Shaw Kenneth
McDonnell Boehnen & Hulbert & Berghoff LLP
Neurogen Corporation
Rahmani Niloofar
Seaman Margaret D.
LandOfFree
Heteroaryl fused aminoalkyl imidazole derivatives: selective... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heteroaryl fused aminoalkyl imidazole derivatives: selective..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroaryl fused aminoalkyl imidazole derivatives: selective... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3979639