Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-05-12
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546174, 546114, 514301, A61K 3147, C07D21512
Patent
active
057505390
ABSTRACT:
Compounds of Formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
REFERENCES:
patent: 5266568 (1993-11-01), Belley et al.
patent: 5270324 (1993-12-01), Zamboni et al.
patent: 5350760 (1994-09-01), Labelle et al.
patent: 5428033 (1995-06-01), Belley et al.
patent: 5438141 (1995-08-01), Labelle et al.
Chauret, et al In Vitro Biotransformations of MK-0476, A New Potent LTD4 Antagonists, Presented at the 10th International Symposium on Microsomes & drug Oxidations, Toronto, Canada Jul. 18-21 1994.
U.S. application No. 07/866,697, Apr. 13, 1992, Gauthier, J.Y., et al (Our Case 18720).
Chauret Nathalie
Dufresne Claude
Gareau Yves
Labelle Marc
Nicoll-Griffith Deborah
Aulakh Charanjit S.
Ivy C. Warren
Merck Frosst Canada
Rose David L.
Yang Mollie M.
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