Heteroaryl diazacycloalkanes, their preparation and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S575000

Reexamination Certificate

active

07064118

ABSTRACT:
The present invention relates to novel heteroaryl diazacycloalkane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

REFERENCES:
patent: 4025617 (1977-05-01), Green et al.
patent: 4163849 (1979-08-01), Lumma, Jr. et al.
patent: 4179563 (1979-12-01), Butler
patent: 4639415 (1987-01-01), Kaneko et al.
patent: 4806536 (1989-02-01), Cross et al.
patent: 6448242 (2002-09-01), Ishiwata et al.
patent: A215643 3 (1985-10-01), None
patent: A221145 7 (1987-02-01), None
patent: A2361489 (1990-04-01), None
patent: A138535 0 (1990-09-01), None
patent: A180217 3 (1997-10-01), None
patent: 1492528 (1977-11-01), None
patent: A19610568 (1996-04-01), None
patent: A1992183 4 (1999-05-01), None
patent: WO 99/42446 (1999-08-01), None
Schmitt et al., Targeting Nicotinic Acetylcholine Receptors: Advances in Molecular Design and Therapies, Annual Reports in Medicinal Chemistry, vol. 35, pp. 41-51, 2000.
Xu et al., Sch. Pharm. Sci., vol. 23, No. 6, pp. 477-480 (1991) Abstract.
Manetti et al., Bioorganic and Medicinal Chemistry, vol. 7, pp. 457-465 (1999).
Georgiev et al., Med. Akad., vol. 27, No. 3, pp. 23-28 (1977) Abstract.
Nielsen et al., J. Med. Chem, vol. 43, pp. 2217-2226 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heteroaryl diazacycloalkanes, their preparation and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heteroaryl diazacycloalkanes, their preparation and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroaryl diazacycloalkanes, their preparation and use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3678274

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.