Heteroaryl compounds useful as inhibitors of E1 activating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S265100, C514S269000, C514S275000, C544S280000, C544S319000, C544S323000, C544S327000

Reexamination Certificate

active

08008307

ABSTRACT:
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

REFERENCES:
patent: 5194446 (1993-03-01), Lo et al.
patent: WO 97/05132 (1997-02-01), None
patent: WO 2004/043955 (2004-05-01), None
patent: WO 2005/037845 (2005-04-01), None
patent: WO 2006/002284 (2006-01-01), None
patent: WO 2006/084281 (2006-08-01), None
patent: WO 2007/092213 (2007-08-01), None
Gura, Systems for identifying New Drugs Are Often Faulty, Cancer Models, Science, vol. 278, No. 5340, pp. 1041-1042, Nov. 1997.
Johnson et al., Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials, British Journal of Cancer (2001) 64(10): 1424-1431.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Xu et al., The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma, Blood, vol. 115, No. 11, pp. 2251-2259, Mar. 2010.
International Search Report and Written Opinion dated Nov. 23, 2007 from International Application No. PCT/US07/017463 corresponding to U.S. Appl. No. 11/890,338.

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