Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-30
2011-08-30
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S265100, C514S269000, C514S275000, C544S280000, C544S319000, C544S323000, C544S327000
Reexamination Certificate
active
08008307
ABSTRACT:
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
REFERENCES:
patent: 5194446 (1993-03-01), Lo et al.
patent: WO 97/05132 (1997-02-01), None
patent: WO 2004/043955 (2004-05-01), None
patent: WO 2005/037845 (2005-04-01), None
patent: WO 2006/002284 (2006-01-01), None
patent: WO 2006/084281 (2006-08-01), None
patent: WO 2007/092213 (2007-08-01), None
Gura, Systems for identifying New Drugs Are Often Faulty, Cancer Models, Science, vol. 278, No. 5340, pp. 1041-1042, Nov. 1997.
Johnson et al., Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials, British Journal of Cancer (2001) 64(10): 1424-1431.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Xu et al., The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma, Blood, vol. 115, No. 11, pp. 2251-2259, Mar. 2010.
International Search Report and Written Opinion dated Nov. 23, 2007 from International Application No. PCT/US07/017463 corresponding to U.S. Appl. No. 11/890,338.
Claiborne Christopher F.
Critchley Stephen
Cullis Courtney
Langston Steven P.
Mizutani Hirotake
Millennium Pharmaceuticals Inc.
Rao Deepak
LandOfFree
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