Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthe

Details Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthe Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthe

1993-06-23

1994-11-01

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514433, 514436, 514438, 514444, 514452, 514460, 514461, 514568, 549 14, 549 21, 549 28, 549 60, 549 78, 549364, 549365, 549370, 549372, 549397, 549414, 549416, 549423, 549468, 549502, 562468, A61K 3138, A61K 31335, A61K 31385, A61K 3135

Patent

active

053608151

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 5225438 (1993-07-01), Dowell et al.
patent: 5252599 (1993-10-01), Girard et al.

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