Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-06-01
2010-06-29
Anderson, James D (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S335100, C548S300100, C514S183000, C514S359000
Reexamination Certificate
active
07745475
ABSTRACT:
Compounds of Formula (I) wherein: R1is hydroxymethyl; R2is selected from —C(O)NR4R5, SO2NR4R5, S(O)pR4and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5is hydrogen or (1-4C)alkyl; or R4and R5together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.
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Johnstone Craig
McKerrecher Darren
Pike Kurt Gordon
Waring Michael James
Anderson James D
AstraZeneca AB
Finn Meghan
Morgan & Lewis & Bockius, LLP
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