Heteroaryl alkyl piperazine derivatives

Details Heteroaryl alkyl piperazine derivatives Heteroaryl alkyl piperazine derivatives

2005-02-01

2005-02-01

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S368000

Reexamination Certificate

active

06849632

ABSTRACT:
Novel compounds of the general formula:and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of diabetes, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

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patent: 6573264 (2003-06-01), Zablocki et al.
patent: 0407780 (1991-01-01), None
patent: WO 0162749 (2001-08-01), None
McCormick et al., “Ranolazine: A Novel Modulator for the Treatment of Angina”, Gen. Pharmac., vol. 30, No. 5, pp. 639-645 (1998).

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