Heteroaryl alkyl alpha substituted peptidylamine calcium channel

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514365, 514326, 546337, 546209, 548204, C07D21330, A61K 3144

Patent

active

061660523

ABSTRACT:
The present invention provides compounds that block calcium channels having the Formula I shown below. ##STR1## The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.

REFERENCES:
patent: 5232929 (1993-08-01), Desai
patent: 5332817 (1994-07-01), Desai et al.
patent: 5420297 (1995-05-01), Matsuo et al.
CA 127:51005, Horwell et al., 1997.
CA 120:45970, Woodruff, 1994.
CA 119:117788, Boden et al., 1997.

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