Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatm

Details Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatm Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatm

1990-10-31

1993-03-23

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514437, 514454, A01N 4356, A01N, A01N 4316

Patent

active

051964457

ABSTRACT:
Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R.sub.4)--, --O--CH(R.sub.4)--, --S(O).sub.n --CH(R.sub.4)--, --CH(R.sub.4)--O--, --CH(R.sub.4)--S(O).sub.n -- --CH(R.sub.4)--CH.sub.2 -- group wherein n is 0, 1 or 2; R.sub.1 represents C.sub.1 -C.sub.6 alkyl, pyridyl or unsubstituted or substituted phenyl; R.sub.2, R.sub.3, and R.sub.4 are as herein defined; and Q is hydrogen, carboxy, C.sub.2 -C.sub.7 -alkoxycarbonyl or a --CON(R.sub.a)R.sub.b group, R.sub.a and R.sub.b being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

REFERENCES:
patent: 4268516 (1981-05-01), Lombardino
Drews "Immunopharmakologie" 1986.
Mercke Manual p. 319-322, 1987.

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