Heteroarotinoid compounds as anticancer agents

Details Heteroarotinoid compounds as anticancer agents Heteroarotinoid compounds as anticancer agents

1987-01-27

1989-05-02

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548469, 549 23, 549 58, 549407, 549462, 556406, C07D30779, C07D31174, C07D33354, C07D20908

Patent

active

048269840

ABSTRACT:
Novel heteroarotinoid compositions characterized by the formulae: ##STR1## where R is H, CH.sub.3 or C.sub.2 H.sub.5 and X is S, S O, O, NCH.sub.3, Si(CH.sub.3).sub.2, N.sup.+ (H)CH.sub.3 [Cl.sup.- ], N.sup.+ (H)CH.sub.3 [Br.sup.- ] or N.sup.+ (alkyl) CH.sub.3 [Cl.sup.- or Br.sup.-) where alkyl is CH.sub.3, C.sub.2 H.sub.5, CH.sub.2 .dbd.CHCH.sub.2 or C.sub.6 H.sub.5 CH.sub.2. Such compositions exhibit activity as anticancer agents.

REFERENCES:
Lovey et al, J. Med. Chem., 1982, 25, pp. 71-75.
Dawson et al, J. Med. Chem, 1983, 26, pp. 1282-1293.
Pawson et al, J. Med. Chem, 1982, 25, pp. 1269-1277.

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