Heteroaromatic inhibitors of fructose 1,6-bisphosphatase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S256000, C514S315000, C514S359000, C514S396000, C544S232000, C546S022000, C546S023000, C548S112000, C548S113000, C548S119000

Reexamination Certificate

active

10636474

ABSTRACT:
Novel FBPase inhibitors of the formula I and Xare useful in the treatment of diabetes and other conditions associated with elevated blood glucose.

REFERENCES:
patent: 3551422 (1970-12-01), Tesoro et al.
patent: 3650670 (1972-03-01), Tesoro et al.
patent: 3657282 (1972-04-01), Christensen et al.
patent: 3822296 (1974-07-01), Christensen et al.
patent: 3931206 (1976-01-01), Bowler et al.
patent: 4000305 (1976-12-01), Bowler et al.
patent: 4046841 (1977-09-01), Foster et al.
patent: 4092323 (1978-05-01), Foster et al.
patent: 4278791 (1981-07-01), Botta et al.
patent: 4876248 (1989-10-01), Bvelieve et al.
patent: 4939130 (1990-07-01), Jaeggi et al.
patent: 4968790 (1990-11-01), DeVries et al.
patent: 5116919 (1992-05-01), Buzinkai et al.
patent: 5133972 (1992-07-01), Ferrini et al.
patent: 5142000 (1992-08-01), Wheland
patent: 5550276 (1996-08-01), Wirth et al.
patent: 5610210 (1997-03-01), Holderbaum et al.
patent: 5658889 (1997-08-01), Gruber et al.
patent: 5728650 (1998-03-01), Fisher et al.
patent: 5728704 (1998-03-01), Mylari et al.
patent: 5731299 (1998-03-01), Ebetino et al.
patent: 5958904 (1999-09-01), Cordi et al.
patent: 5985858 (1999-11-01), Miyata et al.
patent: 6037335 (2000-03-01), Takashima et al.
patent: 6054587 (2000-04-01), Reddy et al.
patent: 6110903 (2000-08-01), Kasibhatla et al.
patent: 6284672 (2001-09-01), Yu
patent: 6284748 (2001-09-01), Dang et al.
patent: 6294672 (2001-09-01), Reddy et al.
patent: 6312662 (2001-11-01), Erion et al.
patent: 6399782 (2002-06-01), Kasibhatla et al.
patent: 6489476 (2002-12-01), Dang et al.
patent: 6756360 (2004-06-01), Erion et al.
patent: 6919322 (2005-07-01), Bookser et al.
patent: 6965033 (2005-11-01), Jiang et al.
patent: 6967193 (2005-11-01), Dang et al.
patent: 2003/0073728 (2003-04-01), van Poelje et al.
patent: 2004/0167178 (2004-08-01), Erion et al.
patent: 2005/0004077 (2005-01-01), Jiang et al.
patent: 2005/0176684 (2005-08-01), Bookser et al.
patent: 2 343 632 (1974-04-01), None
patent: 2 348 632 (1974-04-01), None
patent: 26 41 736 (1977-03-01), None
patent: 40 29 444 (1994-08-01), None
patent: 43 03 648 (1994-08-01), None
patent: 195 01 843 (1996-06-01), None
patent: 0 033 195 (1981-08-01), None
patent: 0 100 718 (1984-02-01), None
patent: 0 186 405 (1986-02-01), None
patent: 0 230 068 (1987-07-01), None
patent: 0 353 969 (1990-02-01), None
patent: 0 354 322 (1990-02-01), None
patent: 0 407 344 (1991-01-01), None
patent: 0 427 799 (1991-05-01), None
patent: 0 243 173 (1991-06-01), None
patent: 0 438 375 (1991-07-01), None
patent: 0 528 760 (1993-02-01), None
patent: 0 559 079 (1993-09-01), None
patent: 0 620 227 (1994-10-01), None
patent: 0 636 630 (1995-02-01), None
patent: 0 034 480 (1970-12-01), None
patent: 2 034 480 (1970-12-01), None
patent: 1343022 (1974-01-01), None
patent: 1 516 347 (1978-07-01), None
patent: 2271113 (1994-04-01), None
patent: 6-306089 (1988-10-01), None
patent: 63-250290 (1988-10-01), None
patent: 90/08155 (1990-07-01), None
patent: 90/10636 (1990-09-01), None
patent: WO92/11269 (1992-07-01), None
patent: WO92/12985 (1992-08-01), None
patent: WO92/19629 (1992-11-01), None
patent: WO93/14081 (1993-07-01), None
patent: WO93/15610 (1993-08-01), None
patent: WO94/07867 (1994-04-01), None
patent: 95/07920 (1995-03-01), None
patent: 95/07920 (1995-03-01), None
patent: WO95/14385 (1995-06-01), None
patent: WO97/24360 (1997-07-01), None
patent: WO98/04528 (1998-02-01), None
patent: WO98/39342 (1998-09-01), None
patent: WO98/39343 (1998-09-01), None
patent: WO98/39344 (1998-09-01), None
patent: 99/45016 (1999-09-01), None
patent: 99/47549 (1999-09-01), None
patent: 00/27401 (2000-05-01), None
patent: 00/38666 (2000-07-01), None
patent: 01/47935 (2001-07-01), None
patent: 01/52825 (2001-07-01), None
patent: 01/66553 (2001-09-01), None
patent: 02/03978 (2002-01-01), None
patent: 06/023515 (2006-03-01), None
Aboujaoude, et al., “Preparation Quasi Quantitative De Phosphonates β-Carbonyles Par L'emploi D'une Base Relais, Le Dipal,”Phosphorus and Sulfur, 25:57-61 (1985).
Arcoria, et al., “Reactions of Triethyl Phosphite with 2-Haloacetyl-furan,-thiophene,-pyrrole and -N-methlpyrrole (1),”J. Het. Chem., 12:215-218 (1975).
Baboulene, M., et al., “Reactivite Du Bromo-3 OXO-2 Propyl Phosphonate De Diethyle Dans La Reaction De Hantzsch,”Phosphorus and Sulfur, 5:87-94 (1978).
Baudy, et al., “Potent Quinoxaline-Spaced Phosphono α-Amino Acids of the AP-6 Type as Competitive NMDA Antagonists: Synthesis and Biological Evaluation,”J. Med. Chem., 36(3):331-342 (1992).
Burke, et al., “Stereoselective Syntheses of the Rhizoxin C(1)-C(9) and C(12)-C(26) Subunits,”Tetrahedron Letters, 39:2239-2242 (1998).
Corsano, et al., A New Synthesis of Unsaturated Phosphonates (*) (**),Gazzetta Chimica Italiana, 119:597-599 (1989).
Diziere, et al., “A New Simple Method for the Synthesis of 1-Alkynylphosphonates using (EtO)2P(O)CCl3as Precursor,”Tetrahedron Letters, 37(11):1783-1786 (1996).
Ebetino, et al., “A Stereoselective Process for the Preparation of Novel Phosphonoalkylphosphinates,”Journal of Organometallic Chemistry, 529:135-142 (1997).
Flitsch, et al., “Reaktionen eins 1,3-bisheterfunktionalisierten Propens mit Aldehyden,” Liebgs,Ann Chem., (1985).
Franchetti, et al., “Acyclic Nucleotides Related to Clitocine: Synthesis and Anti-HIV Activity,”Nucleosides&Nucleotides, 14(3-5):607-610 (1995).
Fujita, et al., “Organic Synthesis Utilizing Thiazolidine and The Related Heterocycles,”Heterocycles, 21(1):41-60 (1984).
Garuti, et al., “Synthesis and Bilogical Evaluation of Some New Phosphates,”Pharmazie, 47, 295-297 (1992).
Gloyna, et al., “Darstellung and H-NMR-spektroskopische Untersuchung von β-substituierten Athylen-phosphonsaure-diathylestern,”Journal f. prakt. Chemie. Band, 832-838 (1974).
Gohda, et al., “Theoretical Evidence of the Existence of a Diazafulvene Intermediate in the Reaction Pathway of Imidazoleglycerol Phosphate Dehydratase: Design of Novel and Potent Heterocycle Structure for the Inhibitor on the Basis of the Electronic Structure-Activity Relationship Study,”Biochemica et Biophysica Acta, 1385:107-114 (1998).
Kim, D., “Synthesis of Pyridylquinoline by a Modified Friedlander Synthesis for the Preparation of Streptonigrin Analogue,”Yakhak Hoeji, 30(2):104-105 (1986).
Kolyamshin, O.A., “Phosphorus -Containing Small Rings. VII* Amino Phosphorus Esters with a 2,2-Dichlorocyclopropyl Fragment,”Russian Journal of Gen. Chem., 63(1):29-33 (1993).
Maier, L., et al., “Organic Phosphorus Compounds 97.1Synthesis and Properties of 1-Amino-2-Aryl- and 2-Pyridyl-Ethylphosphonic Acids and Derivatives,”Phosphorus, Sulfur and Silicon, 62:15-27 (1991).
Maruszewska-Wieczorkowska, et al., “Alkyl and Alkenyl Pyridines. Part VII. 3-(2′-Pyridyl)-Propylphosphonic Acid Alkilo I Alkenylopirydny. VII. Kwas 3-(2′-Pirydylo)-Propylofosfonowy,”Roczniki ChemII Ann Soc. Chim. Polonorom37:1315 (1963).
Maruszewska-Wieczorkowska, et al., “Synthesis of 2-(Pyridyl)ethylphosphonic Acids and Esters,”Chemical Abstracts, 23:1886-1889 (1958).
Menard, et al., “Synthesis and Preliminary Evaluation of Chelating Resins Containing α-aminoalkylphosphonic Groups,”Reactive Polymers, 32:201-212 (1994).
Mikhailyuchenko, et al., “2-Chloro-1-(Diethoxyphosphinyl)Ethyl Isocyanate,”Institute of Organic Chemistry, 47(10):2011-2012 (1977).
Mikityuk, et al., “C-Acylation of Diazomethane with (Diethoxy-phosphinyl)Acetyl Chloride,”All Union Phytopathology Research Institute, 57(7):1488-1489 (1988).
Mori, et al., “Synthesis of Inhibitors of Imadazole Glycerol Phosphate Dehydratase,”J. Am Chem Soc., 117:4411-4412 (1995).
Morita, et al., “Synthesis and Antihypertensive Activities of 1,4-Dihydropyridine-5-phosphonate Derivatives,”Chem. Pharm Bull., 35:3898-3904 (1987).
O'Donnell, et al., “Preparation of

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heteroaromatic inhibitors of fructose 1,6-bisphosphatase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heteroaromatic inhibitors of fructose 1,6-bisphosphatase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroaromatic inhibitors of fructose 1,6-bisphosphatase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3853260

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.