Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-25
2007-12-25
Lambkin, Deborah C. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S256000, C514S315000, C514S359000, C514S396000, C544S232000, C546S022000, C546S023000, C548S112000, C548S113000, C548S119000
Reexamination Certificate
active
10636474
ABSTRACT:
Novel FBPase inhibitors of the formula I and Xare useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
REFERENCES:
patent: 3551422 (1970-12-01), Tesoro et al.
patent: 3650670 (1972-03-01), Tesoro et al.
patent: 3657282 (1972-04-01), Christensen et al.
patent: 3822296 (1974-07-01), Christensen et al.
patent: 3931206 (1976-01-01), Bowler et al.
patent: 4000305 (1976-12-01), Bowler et al.
patent: 4046841 (1977-09-01), Foster et al.
patent: 4092323 (1978-05-01), Foster et al.
patent: 4278791 (1981-07-01), Botta et al.
patent: 4876248 (1989-10-01), Bvelieve et al.
patent: 4939130 (1990-07-01), Jaeggi et al.
patent: 4968790 (1990-11-01), DeVries et al.
patent: 5116919 (1992-05-01), Buzinkai et al.
patent: 5133972 (1992-07-01), Ferrini et al.
patent: 5142000 (1992-08-01), Wheland
patent: 5550276 (1996-08-01), Wirth et al.
patent: 5610210 (1997-03-01), Holderbaum et al.
patent: 5658889 (1997-08-01), Gruber et al.
patent: 5728650 (1998-03-01), Fisher et al.
patent: 5728704 (1998-03-01), Mylari et al.
patent: 5731299 (1998-03-01), Ebetino et al.
patent: 5958904 (1999-09-01), Cordi et al.
patent: 5985858 (1999-11-01), Miyata et al.
patent: 6037335 (2000-03-01), Takashima et al.
patent: 6054587 (2000-04-01), Reddy et al.
patent: 6110903 (2000-08-01), Kasibhatla et al.
patent: 6284672 (2001-09-01), Yu
patent: 6284748 (2001-09-01), Dang et al.
patent: 6294672 (2001-09-01), Reddy et al.
patent: 6312662 (2001-11-01), Erion et al.
patent: 6399782 (2002-06-01), Kasibhatla et al.
patent: 6489476 (2002-12-01), Dang et al.
patent: 6756360 (2004-06-01), Erion et al.
patent: 6919322 (2005-07-01), Bookser et al.
patent: 6965033 (2005-11-01), Jiang et al.
patent: 6967193 (2005-11-01), Dang et al.
patent: 2003/0073728 (2003-04-01), van Poelje et al.
patent: 2004/0167178 (2004-08-01), Erion et al.
patent: 2005/0004077 (2005-01-01), Jiang et al.
patent: 2005/0176684 (2005-08-01), Bookser et al.
patent: 2 343 632 (1974-04-01), None
patent: 2 348 632 (1974-04-01), None
patent: 26 41 736 (1977-03-01), None
patent: 40 29 444 (1994-08-01), None
patent: 43 03 648 (1994-08-01), None
patent: 195 01 843 (1996-06-01), None
patent: 0 033 195 (1981-08-01), None
patent: 0 100 718 (1984-02-01), None
patent: 0 186 405 (1986-02-01), None
patent: 0 230 068 (1987-07-01), None
patent: 0 353 969 (1990-02-01), None
patent: 0 354 322 (1990-02-01), None
patent: 0 407 344 (1991-01-01), None
patent: 0 427 799 (1991-05-01), None
patent: 0 243 173 (1991-06-01), None
patent: 0 438 375 (1991-07-01), None
patent: 0 528 760 (1993-02-01), None
patent: 0 559 079 (1993-09-01), None
patent: 0 620 227 (1994-10-01), None
patent: 0 636 630 (1995-02-01), None
patent: 0 034 480 (1970-12-01), None
patent: 2 034 480 (1970-12-01), None
patent: 1343022 (1974-01-01), None
patent: 1 516 347 (1978-07-01), None
patent: 2271113 (1994-04-01), None
patent: 6-306089 (1988-10-01), None
patent: 63-250290 (1988-10-01), None
patent: 90/08155 (1990-07-01), None
patent: 90/10636 (1990-09-01), None
patent: WO92/11269 (1992-07-01), None
patent: WO92/12985 (1992-08-01), None
patent: WO92/19629 (1992-11-01), None
patent: WO93/14081 (1993-07-01), None
patent: WO93/15610 (1993-08-01), None
patent: WO94/07867 (1994-04-01), None
patent: 95/07920 (1995-03-01), None
patent: 95/07920 (1995-03-01), None
patent: WO95/14385 (1995-06-01), None
patent: WO97/24360 (1997-07-01), None
patent: WO98/04528 (1998-02-01), None
patent: WO98/39342 (1998-09-01), None
patent: WO98/39343 (1998-09-01), None
patent: WO98/39344 (1998-09-01), None
patent: 99/45016 (1999-09-01), None
patent: 99/47549 (1999-09-01), None
patent: 00/27401 (2000-05-01), None
patent: 00/38666 (2000-07-01), None
patent: 01/47935 (2001-07-01), None
patent: 01/52825 (2001-07-01), None
patent: 01/66553 (2001-09-01), None
patent: 02/03978 (2002-01-01), None
patent: 06/023515 (2006-03-01), None
Aboujaoude, et al., “Preparation Quasi Quantitative De Phosphonates β-Carbonyles Par L'emploi D'une Base Relais, Le Dipal,”Phosphorus and Sulfur, 25:57-61 (1985).
Arcoria, et al., “Reactions of Triethyl Phosphite with 2-Haloacetyl-furan,-thiophene,-pyrrole and -N-methlpyrrole (1),”J. Het. Chem., 12:215-218 (1975).
Baboulene, M., et al., “Reactivite Du Bromo-3 OXO-2 Propyl Phosphonate De Diethyle Dans La Reaction De Hantzsch,”Phosphorus and Sulfur, 5:87-94 (1978).
Baudy, et al., “Potent Quinoxaline-Spaced Phosphono α-Amino Acids of the AP-6 Type as Competitive NMDA Antagonists: Synthesis and Biological Evaluation,”J. Med. Chem., 36(3):331-342 (1992).
Burke, et al., “Stereoselective Syntheses of the Rhizoxin C(1)-C(9) and C(12)-C(26) Subunits,”Tetrahedron Letters, 39:2239-2242 (1998).
Corsano, et al., A New Synthesis of Unsaturated Phosphonates (*) (**),Gazzetta Chimica Italiana, 119:597-599 (1989).
Diziere, et al., “A New Simple Method for the Synthesis of 1-Alkynylphosphonates using (EtO)2P(O)CCl3as Precursor,”Tetrahedron Letters, 37(11):1783-1786 (1996).
Ebetino, et al., “A Stereoselective Process for the Preparation of Novel Phosphonoalkylphosphinates,”Journal of Organometallic Chemistry, 529:135-142 (1997).
Flitsch, et al., “Reaktionen eins 1,3-bisheterfunktionalisierten Propens mit Aldehyden,” Liebgs,Ann Chem., (1985).
Franchetti, et al., “Acyclic Nucleotides Related to Clitocine: Synthesis and Anti-HIV Activity,”Nucleosides&Nucleotides, 14(3-5):607-610 (1995).
Fujita, et al., “Organic Synthesis Utilizing Thiazolidine and The Related Heterocycles,”Heterocycles, 21(1):41-60 (1984).
Garuti, et al., “Synthesis and Bilogical Evaluation of Some New Phosphates,”Pharmazie, 47, 295-297 (1992).
Gloyna, et al., “Darstellung and H-NMR-spektroskopische Untersuchung von β-substituierten Athylen-phosphonsaure-diathylestern,”Journal f. prakt. Chemie. Band, 832-838 (1974).
Gohda, et al., “Theoretical Evidence of the Existence of a Diazafulvene Intermediate in the Reaction Pathway of Imidazoleglycerol Phosphate Dehydratase: Design of Novel and Potent Heterocycle Structure for the Inhibitor on the Basis of the Electronic Structure-Activity Relationship Study,”Biochemica et Biophysica Acta, 1385:107-114 (1998).
Kim, D., “Synthesis of Pyridylquinoline by a Modified Friedlander Synthesis for the Preparation of Streptonigrin Analogue,”Yakhak Hoeji, 30(2):104-105 (1986).
Kolyamshin, O.A., “Phosphorus -Containing Small Rings. VII* Amino Phosphorus Esters with a 2,2-Dichlorocyclopropyl Fragment,”Russian Journal of Gen. Chem., 63(1):29-33 (1993).
Maier, L., et al., “Organic Phosphorus Compounds 97.1Synthesis and Properties of 1-Amino-2-Aryl- and 2-Pyridyl-Ethylphosphonic Acids and Derivatives,”Phosphorus, Sulfur and Silicon, 62:15-27 (1991).
Maruszewska-Wieczorkowska, et al., “Alkyl and Alkenyl Pyridines. Part VII. 3-(2′-Pyridyl)-Propylphosphonic Acid Alkilo I Alkenylopirydny. VII. Kwas 3-(2′-Pirydylo)-Propylofosfonowy,”Roczniki ChemII Ann Soc. Chim. Polonorom37:1315 (1963).
Maruszewska-Wieczorkowska, et al., “Synthesis of 2-(Pyridyl)ethylphosphonic Acids and Esters,”Chemical Abstracts, 23:1886-1889 (1958).
Menard, et al., “Synthesis and Preliminary Evaluation of Chelating Resins Containing α-aminoalkylphosphonic Groups,”Reactive Polymers, 32:201-212 (1994).
Mikhailyuchenko, et al., “2-Chloro-1-(Diethoxyphosphinyl)Ethyl Isocyanate,”Institute of Organic Chemistry, 47(10):2011-2012 (1977).
Mikityuk, et al., “C-Acylation of Diazomethane with (Diethoxy-phosphinyl)Acetyl Chloride,”All Union Phytopathology Research Institute, 57(7):1488-1489 (1988).
Mori, et al., “Synthesis of Inhibitors of Imadazole Glycerol Phosphate Dehydratase,”J. Am Chem Soc., 117:4411-4412 (1995).
Morita, et al., “Synthesis and Antihypertensive Activities of 1,4-Dihydropyridine-5-phosphonate Derivatives,”Chem. Pharm Bull., 35:3898-3904 (1987).
O'Donnell, et al., “Preparation of
Agurwal Atul
Dang Qun
Erion Mark D.
Kasibhatla Srinivas Rao
Reddy K. Raja
Lambkin Deborah C.
Metabasis Therapeutics, Inc.
Saliwanchik Lloyd & Saliwanchik
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