Heteroaromatic glucokinase activators

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S128000, C548S134000, C548S139000, C548S195000, C548S214000

Reexamination Certificate

active

06951945

ABSTRACT:
2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

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patent: WO 00/26202 (2000-05-01), None
Rodier et al., Acta Crystallogr., C46, p. 154-156 (1990).
Robert et al., Eur. J. Med. Chem., vol. 29, pp. 841-854 (1994).
Spickett et al., Eur. J. Med. Chem.—Chimica Therapeutica, vol. 11(1), pp. 7-12 (1976).
Bhat et al., Inst. Chemists (India), vol. 61, pp. 134-136 (1989).
Spielman, M.A., et. al. J. Am. Chem. Soc., 70, pp. 4189-4191 (1948).

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