Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-12-11
1987-05-05
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514349, 514350, 514351, 514354, 514356, 514423, 514424, 514426, 514427, 546300, 546334, 546312, 546141, 548375, 548378, 548543, 548557, 548558, 548561, 548483, 548484, 544406, 544408, 544409, 544336, 546143, 546146, 546149, 546153, 546156, 546157, 546158, 546159, 546162, 546164, 548493, 548503, 548506, 544298, 544315, 544319, 544334, 544335, A61K 3140, A61K 3133, C07D21184, C07D22702, C07D21712, C07D21722, C07D20912, C07D20904
Patent
active
046633340
ABSTRACT:
Heterocyclic acetylenes of the formula (I): ##STR1## wherein Y is alkyl, alkoxy, alkoxyalkyl, chloro, fluoro, bromo or carboxamidoalkyl and R.sup.1 is hydrogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl, chloro, fluoro or dialkylamino, m is 0-2, R.sup.2 is branched alkyl and Het is an aromatic heterocycle. The acetylenes are useful in treating hypertension and/or angina.
REFERENCES:
patent: 3590084 (1971-06-01), Peperkamp et al.
patent: 3914432 (1975-10-01), Koppe et al.
patent: 3959338 (1976-05-01), Koppe et al.
patent: 4010158 (1977-03-01), Koppe et al.
patent: 4412856 (1983-11-01), Brunner et al.
Jiles Henry R.
Levy David J.
McNeilab Inc.
Richter J.
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