Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as

Details Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as

1996-02-07

1997-11-18

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514367, 514394, 514395, 514415, 548221, 5483071, 5483101, 548509, A61K 3140, A61K 31415, A61K 3142, C07D26358, C07D23522

Patent

active

056888228

ABSTRACT:
Compounds of the formula: ##STR1## Formula I and the pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising a therapeutically-effective amount of the compounds or salts in combination with a pharmaceutically-acceptable carrier and methods for treating 5-lipoxygenase mediated conditions, inflammation-associated disorders and allergies.

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patent: 5081253 (1992-01-01), Santilli et al.
patent: 5280047 (1994-01-01), Mueller
S. A. Zaotova, et al. "Synthesis and Biological Activity of Substituted Sulfides of Indole and Benzofuran", Khim-Farm. Zh., 26 (1), 52-55.
Crawley GC, Dowell RL, Edwards PN, Foster SJ, McMillan RM, WalkerERH, Waterson D. J. Med. Chem. 35, 2600-2609 1992.
Gallin Jl, Goldstein IM, Snyderman R. "Inflammation. Basic Principles and Clinical Correlates", Raven Press, New York, p. 1130 1992.

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