Heteroalkylamides of (8-.beta.)-1-alkyl-6-(substituted)ergolines

Details Heteroalkylamides of (8-.beta.)-1-alkyl-6-(substituted)ergolines Heteroalkylamides of (8-.beta.)-1-alkyl-6-(substituted)ergolines

1988-12-19

1990-02-20

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 69, A61K 3148, C07D45706, C07D40114

Patent

active

049026917

ABSTRACT:
This invention provides (8.beta.)-N-heteroalkyl-1-alkyl-6-(substituted)ergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.

REFERENCES:
patent: 2997470 (1961-08-01), Pioch
patent: 3228944 (1966-01-01), Bernardi et al.
patent: 3904633 (1975-09-01), Mago nee Karacsony et al.
patent: 4101552 (1978-07-01), Mago nee Karacsony et al.
Chemical Abstracts 106:5306w (1987).
Chemical Abstracts 77:34752b (1972).
Chemical Abstracts 65:3924f (1966).

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