Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
2004-07-23
2009-06-09
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C424S186100, C424S192100, C424S193100, C424S196110, C424S201100, C530S350000, C536S023100, C435S320100, C435S252300, C435S069300, C435S069700
Reexamination Certificate
active
07544361
ABSTRACT:
A heteropentamer composed of a fusion monomer (32) comprising a fusion protein of an antigenic amino acid sequence and an amino acid sequence of a monomer of a mucous membrane-binding protein and a nonfusion monomer (20) of an amino acid sequence of a monomer of a mucous membrane-binding protein. A homopentamer composed of a fusion monomer including a fusion protein of an antigen derived from an envelope protein of Japanese encephalitis virus and an amino acid sequence of a monomer of a mucous membrane-binding protein. These heteropentamer and the homopentamer can be used as a vaccine.
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Tetsuya Harakuni, et al. “Heteropentameric Cholera Toxin B Subunit Chimeric Molecules Genetically Fused to a Vaccine Antigen Induce Systemic and Mucosal Immune Responses: a Potential new Strategy To Target Recombinant Vaccine Antigens to Mucosal Immune Systems” infection and Immunity vol. 73, No. 9, XP-002461843, Sep. 2005, pp. 5654-5665.
Arakawa Takeshi
Kikukawa Masanao
Matsumoto Yasunobu
Sato Yoshiya
Shimabukuro Isao
Advanced Medical Biological Science Institute Co. Ltd.
Mosher Mary E
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
University of the Ryukyus
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