Hetero isonipecotic modulators of vanilloid VR1 receptor

Details Hetero isonipecotic modulators of vanilloid VR1 receptor Hetero isonipecotic modulators of vanilloid VR1 receptor

2005-06-27

2009-11-24

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C514S227800

Reexamination Certificate

active

07622579

ABSTRACT:
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.

REFERENCES:
patent: WO 96/10022 (1996-04-01), None
patent: WO 97/06802 (1997-02-01), None
patent: WO 98/06705 (1998-02-01), None
patent: WO 03/068749 (2003-08-01), None
patent: WO 03/103669 (2003-12-01), None
patent: WO 2004/035549 (2004-04-01), None
patent: WO 2004/101546 (2004-11-01), None
Chemcats 2032356618 , RN 909501-10-6 (2007).
Lee et al. “anlysis of structure . . . ” Bioorg. Med. chem. v. 12, p. 3411-3420 (2004).
Suh et al. “Nobel non-vanilloid . . . ” Bioorg. Med. Chem. Lett. v.13, p. 4389-4393 (2003).
Szallasi et al. “Vanilloid receptor . . . ” J. Med. Chem. v. 47 (11) p. 2717-2723 (2004).
Brown, G.R. et al., “A Novel Series of 4-Piperidinopyridine and 4-Piperidinopyrimidine inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase”, Journal of Medicinal Chemistry, vol. 43, No. 26, 2000, pp. 4964-4972.
Brown, G.R. et al., “Novel 4-Piperidinopyridine Inhibitors of Oxidosqualene Cyclase-Lanosterol Synthase Derived by Consideration of Inhibitor pKa”, Bioorganic & Medicinal Chemistry Letters, vol. 11, 2001, pp. 2213-2216.
Walpole, C.S.J. et al., “The discovery of Capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin”, Journal of Medicinal chemistry, American Chemical Society, Washington, US, vol. 37, 1994, pp. 1942-1954.
Brown, G.R. et al., “A Novel Series of 4-Piperidinopyridine and 4-Piperidinopyrimidine inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase”, Journal of Medicinal Chemistry, vol. 43, No. 26, 2000, pp. 4964-4972.

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