Hetero-bridge substituted 8-arylquinoline pde4 inhibitors

Details Hetero-bridge substituted 8-arylquinoline pde4 inhibitors Hetero-bridge substituted 8-arylquinoline pde4 inhibitors

2006-12-05

2006-12-05

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S311000, C546S173000

Reexamination Certificate

active

07144896

ABSTRACT:
8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one of the bridge atoms is not carbon, are PDE4 inhibitors.

REFERENCES:
patent: 6919353 (2005-07-01), Dube et al.
patent: WO 94/22852 (1994-10-01), None
patent: WO 01/46151 (2001-06-01), None
patent: WO 02/069970 (2002-09-01), None
patent: WO 03/002118 (2003-01-01), None
patent: WO 03/078397 (2003-09-01), None
Catherine Burnouf, et al, “Recent Advances in PDE4 Inhibitors as Immunoregulators and Anti-Inflammatory Drugs”, Current Pharmaceutical Design, vol. 8, pp. 1255-1296, 2002.
Peter Norman, “PDE4 Inhibitors: sustained Patenting Activity As Leading Drugs Near The Market”, Expert Opinion on therapeutic Patents, vol. 10(9), pp. 1415-1427, 2000.

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