Hetero-benzazepine derivatives and their pharmaceutical use

Details Hetero-benzazepine derivatives and their pharmaceutical use Hetero-benzazepine derivatives and their pharmaceutical use

1983-02-10

1984-10-16

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

424244, 424263, 2602393B, 2602393T, A61K 3155, C07D51304

Patent

active

044774648

ABSTRACT:
Disclosed are variously substituted 3-(carboxymethylamino)-(1,5-benzothiazepin-4-one, 1,5-benzoxazepin-4-one and 1,5-benzodiazepin-4-one)-5-alkanoic acids and derivatives as angiotensin-converting enzyme inhibitors and antihypertensive agents. Their synthesis, pharmaceutical compositions thereof, and methods of threatment utilizing such compounds are included.

REFERENCES:
patent: 3661927 (1972-05-01), Zimkovic
patent: 3748321 (1973-07-01), Krapcho
patent: 4410520 (1983-10-01), Watthey
patent: 4416819 (1983-11-01), Nagao et al.
Levai A., Acta Chimica Academie Scientiariam Hungaricae, vol. 102, pp. 141-142, (1979).
Levai A., Pharmazie, vol. 35, pp. 680-681, (1980).
Ito, S., Bull. Chem. Soc. Jap., vol. 43, p. 1824, (1970), Chem Abstr. vol. 92, item 22531a.
Evans et al., J. Chem. Soc., (1965), pp. 4806-4812.
G. S. Sidhu et al., J. Chem. Soc., (1966), pp. 969-971.

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