Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-07-12
2011-07-12
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S438000, C548S469000, C549S462000, C549S029000
Reexamination Certificate
active
07977370
ABSTRACT:
The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
REFERENCES:
patent: 4065573 (1977-12-01), Lednicer
patent: 4115589 (1978-09-01), Lednicer
patent: 2009/0247505 (2009-10-01), Zemolka et al.
patent: 2009/0247530 (2009-10-01), Nolte et al.
patent: 2009/0247561 (2009-10-01), Zemolka et al.
patent: 2009/0247591 (2009-10-01), Zemolka et al.
patent: 2011/0059999 (2011-03-01), Frormann et al.
patent: 071066 (2010-05-01), None
patent: 071067 (2010-05-01), None
patent: 071068 (2010-05-01), None
patent: 073841 (2010-12-01), None
patent: 2009228637 (2009-10-01), None
patent: 2009228642 (2009-10-01), None
patent: 2009228643 (2009-10-01), None
patent: 2009228645 (2009-10-01), None
patent: 2009228647 (2009-10-01), None
patent: 2009228648 (2009-10-01), None
patent: 2718209 (2009-10-01), None
patent: 2719735 (2009-10-01), None
patent: 2719736 (2009-10-01), None
patent: 2719739 (2009-10-01), None
patent: 2719742 (2009-10-01), None
patent: 2719743 (2009-10-01), None
patent: 28 39 891 (1979-04-01), None
patent: 2260022 (2009-10-01), None
patent: 2257526 (2010-12-01), None
patent: 2260021 (2010-12-01), None
patent: 2260042 (2010-12-01), None
patent: 2271613 (2011-01-01), None
patent: 2280941 (2011-02-01), None
patent: 20100132048 (2010-12-01), None
patent: 20100136521 (2010-12-01), None
patent: 2010009955 (2010-09-01), None
patent: 2010010337 (2010-10-01), None
patent: 2010010339 (2010-10-01), None
patent: 2010010407 (2010-10-01), None
patent: 2010010446 (2010-11-01), None
patent: 2010010448 (2010-11-01), None
patent: 16502009 (2009-11-01), None
patent: 16892009 (2009-11-01), None
patent: 16572009 (2009-12-01), None
patent: 18222009 (2009-12-01), None
patent: 18232009 (2009-12-01), None
patent: 01 87838 (2001-11-01), None
patent: 02 90330 (2002-05-01), None
patent: 03 008370 (2002-07-01), None
patent: 02 090317 (2002-11-01), None
patent: 03 008731 (2003-01-01), None
patent: 03 080557 (2003-01-01), None
patent: 2004 043899 (2004-05-01), None
patent: 2004 043900 (2004-05-01), None
patent: 2004 043902 (2004-05-01), None
patent: 2004 043909 (2004-05-01), None
patent: 2004 043949 (2004-05-01), None
patent: 2004 043967 (2004-05-01), None
patent: 2005 063769 (2005-07-01), None
patent: 2005 066183 (2005-07-01), None
patent: 2005 110970 (2005-11-01), None
patent: 2005 110971 (2005-11-01), None
patent: 2005 110973 (2005-11-01), None
patent: 2005 110974 (2005-11-01), None
patent: 2005 110975 (2005-11-01), None
patent: 2005 110976 (2005-11-01), None
patent: 2005 110977 (2005-11-01), None
patent: 2006 018184 (2006-02-01), None
patent: 2006 108565 (2006-10-01), None
patent: 2007 079927 (2007-07-01), None
patent: 2007 079928 (2007-07-01), None
patent: 2007 079930 (2007-07-01), None
patent: 2007 079931 (2007-07-01), None
patent: 2007 124903 (2007-11-01), None
patent: 2008 009416 (2008-01-01), None
patent: 2008009415 (2008-01-01), None
patent: 2009 011813 (2009-10-01), None
patent: 2009118163 (2009-10-01), None
patent: 2009118168 (2009-10-01), None
patent: 2009118169 (2009-10-01), None
patent: 2009118171 (2009-10-01), None
patent: 2009118173 (2009-10-01), None
patent: 2009118174 (2009-10-01), None
Katritzky et al., Synthesis 1989, pp. 66-79.
Shiner et al., J. am. Chem. Soc., 103, 1981, pp. 436-442.
Xia et al., Organic Letters, vol. 7, No. 7, 2005, pp. 1315-1318.
Messina et al., Tetrahedron, Asymmetry 11, 2000, pp. 1681-1685.
Greene et al., Protective Groups in Organic Synthesis; Wiley Interscience Publication; 3rd Edition, 1999.
Jirkovsky et al., J. Heterocycl. Chem., 12, 1975, pp. 937-940.
Beck et al., J. Chem. Soc. Perkin 1, 1992, pp. 813-822.
Shinada et al., Tetrahedron Letters, vol. 39, 1996, pp. 7099-7102.
Garden et al., Tetrahedron, 58, 2002, pp. 8399-8412.
Lednicer et al., J. Med. Chem., 23, 1980, pp. 424-430.
Williams et al., J. Org. Chem. 1980, 45, pp. 5082-5088.
Bandini et al. J. Org. Chem. 67, 2002, pp. 5386-5389.
Davis et al., J. Med. Chem. 35, 1992, pp. 177-184.
Yamagishi et al., J. Med. Chem. 35, 1992, pp. 2085-2094.
Gleave et al.; Bioorganic & Medicinal Chemistry Letters 8, 1998, pp. 1231-1236.
Sandmeyer, Helv.Chim.Acta; 2; 1919; 239 (cited on p. 53 of the specification).
Katz et al.; J. Med. Chem. 31, 1988; pp. 1244-1250.
Bac et al. Tetrahedron Letters, 1988, vol. 29, pp. 2819-2822.
Kato et al. J. Fluorine Chemistry, 99, 1999, pp. 5-7.
Kim et al., J.M, Pain, 50 (1992) 355-363.
Piper, et al; Journal of Medicinal Chemistry, US American Chemical Society, Washington, No. 9, Jan. 1, 1966; pp. 911-920.
Gilbert, et al; Journal of the American Chemical Society, 1950, No. 72, pp. 2411-2417.
Chu, et al.; Tetrahedron, Elsevier Science Publishers, Amsterdam, NL, No. 62, 2006, pp. 5536-5548.
Elliott et al. Bioorg. Med. Chem. Lett.; EN; 16; 2006; 2929.
Ma et al. J. Org. Chem. 2001, 66, 4525.
Bavetsias et al., “Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents”, J. Med. Chem, No. 43, pp. 1910-1926, (2000).
Catterall et al., “Binding of Batrachotoxinin a 20-α-Benzoate to a Receptor Site Associated with Sodium Channels in Synaptic Nerve Ending Particles”, The Journal of Biological Chemistry, vol. 256, No. 17, pp. 8922-8927, Sep. 10, 1981.
Dirat et al., “Expeditious systhesis of novel NK1 antagonists based on a 1,2,4-trisubstituted cyclohexane”, Tetrahedron Letters, No. 47, pp. 1295-1298, (2006).
Hamzé et al., “Systhesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral B3- and α-Amino Acids from Fmoc-Protected Aspartic Acid”, J. Org. Chem. No. 68, pp. 7316-7321, (2003).
Hashmi et al., “Gold Catalysis: Mild Conditions for the Synthesis of Oxazoles from N-Propargylcarboxamides and Mechanistic Aspects”, Organic Letters, vol. 6, No. 23, pp. 4391-4394, (2004).
Lee et al., “Introduction of Heterocycles at the 2-position of Indoline as Ester Bioisosteres”, Bull. Koren Chem. Soc. vol. 25, No. 2 pp. 207-212, (2004).
Morwick et al., “A Practical Approach to the Synthesis of 2,4-Disubstituted Oxazoles from Amino Acids”, Organic Letters, vol. 4, No. 16, pp. 2665-2668, (2002).
Thompson et al., “Structure-Based Design of Cathepsin K Inhibitors Containing a Benzyloxy-Substituted Benzoyl Peptidomimetic”, Journal of Medical Chemistry, vol. 41, No. 21, 1998, pp. 3923-3927.
Finlayson, et al., European Journal of Pharmacology, 412 (2001), pp. 203-212.
Corey et al., “A Synthetic Method for Formyl-ethynyl Conversion (RCHO-RC=CH or RC=CR')”, Tetrahedron Letters, No. 36, pp. 3769-3772, (1972).
D'Amour et al., “A Method for Determining Loss of Pain Sensation”, The Biologic Research Laboratory, pp. 74-79, Jan. 27, 1941.
Harned et al., “High-load, Soluble Oligomeric Benzenesulfonyl Azide: Application to Facile Diazo-transfer Reactions”, Tetrahedron, No. 61, pp. 12093-12099, (2005).
Katritzky et al., “New Synthesis of Amines and Amides Mediated by Additions of Benzotriazole to Enamines and Enamides and Transformations of the Adducts”, Synthesis, pp. 1295-1298, Dec. 1992.
Kudzma et al., “4-Phenyl- and a 4-Heteroaryl-4-anilidopiperidines. A Novel Class of Analgesic and Anesthetic Agents1”, J. Med. Chem. No. 32, pp. 2534-2542, (1989).
Layer, Robert W. “The Chemistry of Imines”, B.F. Goodrich Co., Research Center, pp. 489-510, Dec. 7, 1962.
Lednicer et al., “4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring”, The Upjohn Company, Research Laboratories, Aug. 7, 1979.
Maddox et al., “The Synthesis of Phencyclidine and Other 1-Arylcyclohexylamines”, Research Laboratories, Parke, Davis and Company; vol. 8, pp. 230-235, Mar. 1965.
Prashad et al., “1,2,3-Triazole as a Safer and Practical Substitute for Cyanide in the Bruylants Reaction for
Bálint József
Englberger Werner
Henkel Birgitta
Linz Klaus
Nolte Bert
Chu Yong
Gruenenthal GmbH
Norris McLaughlin & Marcus P.A.
Rodriguez-Garcia Valerie
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