Herpesviruses transformed to express GD in vitro

Details Herpesviruses transformed to express GD in vitro Herpesviruses transformed to express GD in vitro

1995-04-19

1997-10-14

Elliott, George G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242021, 4242041, 424816, 4352351, 4353201, A61K 3900, C12N 701, C12N 702

Patent

active

056769520

ABSTRACT:
Herpesviruses naturally deficient in gD, that is to say not expressing their gD gene in vitro or not possessing this gene, are transformed to express gD in vitro. This transformation by genetic recombination can consist in replacement of the natural promoter by another one or insertion of an expression cassette containing gD and a promoter. The invention also relates to these viruses incorporating a gene coding for an antigen of interest, to the vaccines obtained and to the methods of culture thus improved. The invention relates in particular to avian herpesviruses, especially MDV, and the VZV virus.

REFERENCES:
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patent: 5252716 (1993-10-01), Velicer et al.
patent: 5252717 (1993-10-01), Velicer et al.
patent: 5378467 (1995-01-01), Bexendale
Gibson M. G., et al "Insertion Mutants of Herpes Surplex virus have a Duplication of the Glycoprotein DGene and Express Two Different forms of Glycoprotein D.". Journal of Virology, Nov 1983, vol. 48 No 2 p 396-404.
Lee et al, "Expression of Herpes Simplex virus Glycoprotein C from a DNA Fragment inserted into the Thiaidine Kinase Gene of this virus".
Proc. Natl. Acad. Sci. vol. 79 pp. 6612-6616 Nov 1982.
X. Tan and L.F. Velicer Abstracts of the XVIII International Herpesvirus Workshop, University of Pittsburgh Medical Center, Pittsburgh, PA 1993, p. A 145.
Zelnik V. et al, Proceedings 19th World's Poultry Congress, pp. 114-117 Amsterdam, 19-24 Sep. 1992.
Brunovskis P. et al, Proceedings 19th World's Poultry Congress, pp. 114-117 Amsterdam 19-24 Sep. 1992.
Ross, L.J.N et al, J. Gen Virol, 1991, 72 949-954.
Zelnik V. et al, J. Gen. Virol, 1993 2151-2162.

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