Herpesvirus particles and vaccine

Details Herpesvirus particles and vaccine Herpesvirus particles and vaccine

1993-07-22

1995-01-24

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

530350, 4351721, 4352351, A61K 3912, C12N 704, C12N 1500, C07K 300

Patent

active

053841220

ABSTRACT:
In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantially free of infectious virions, e.g. by allowing an appropriate temperature-sensitive mutant to replicate at its non-permissive temperature, and such L-particles are useful as a component of a vaccine against the herpesvirus. They can also be prepared to contain a foreign protein or peptide, by use of a recombinant herpesvirus.

REFERENCES:
patent: 4999296 (1991-03-01), Kit et al.
Shih et al "Expression of Heptitis B. virus . . . " Proc. Natl Acad. Sci. USA, vol. 81, 1984, pp. 5867-5870.
Szilagyi et al, 1991, J. Gen. Virol. 72:661-668.
Preston, et al., 1093, "Identification and Characterization of a herpes . . . " J. of Virology 45(3):1056-1064.
Willey, et al., 1988, "In Vitro Mutagenesis Identifies a Region . . . " J. of Virology 63z;139-147.
Irmiere, et al., 1983, "Isolation and Characterization of . . . " Virology 130-118-133.

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