Herpes zinc finger motifs

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Details

C435S007100, C435S069100, C435S007930

Reexamination Certificate

active

06946253

ABSTRACT:
The present invention relates to a method for detecting an agent for use in the treatment of herpes virus infection and use of known agents, such as 2,2′-dithiobisbenzamide (DIBA) and azodicarbonamide (ADA), and unknown agents, which selectively eject zinc bound to a zinc finger protein, for the manufacture of a medicament for the treatment of herpesvirus infections.

REFERENCES:
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patent: 5767135 (1998-06-01), Fernandez-Pol
patent: 5874094 (1999-02-01), Costello
patent: 0 524 961 (1994-07-01), None
patent: WO 98/54311 (1998-12-01), None
Ingram et al , Journal of General Virology, 1996, vol. 77, 1874-1851.
Beerheide et al. “Potential Drugs Against Cervical Cancer: Zinc-Ejecting Inhibitors of the Human Papillomavirus Type 16 E6 Oncoprotein”Journal of the National Cancer Institute91(14): 1211-1220 (1999).
Communication Pursuant to Article 115(2) EPC for European Application No. EP-A-1299725 submitted on Feb. 14, 2005.
Gaudin et al. “Conformational Flexibility and Polymerization of Vesicular Stomatitis Virus Matrix Protein”Journal of Molecular Biology274(5): 816-825 (1997).
Maynard et al “Reativity of the HIV-1 Nucleocapsid Protein p7 Zinc Finger Domains from the Perspective of Density-Functional Theory”Proc Natl Acad Sci USA95: 11578-11583 (1998).
Rice et al “Azodicarbonamide Inhibits HIV-1 Replication by Targeting the Nucleocapsid Protein”Future Medicine3(3): 341-345 (1997).
Vandeleve et al. “Letter to the Editor: ADA, A Potential Anti-HIV Drug”AIDS Research and Human Retroviruses12(7): 567-568 (1996).
Zhi et al. “Self-Interaction of the Herpes Simplex Virus Type 1 Regulatory Protein ICP27”Virology257(2): 341-351 (1999).
Colasanti M. et al. “S-nitrosylation of viral proteins: molecular bases for antiviral effect of nitric oxide”International Union of Biochemistry and Molecular Biology48(1):25-31 (Jul. 1998) Abstract Only.
International Search Report corresponding to PCT GB01-03114 mailed on Mar. 11, 2002.

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