Herpes viruses for immune modulation

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

Reexamination Certificate

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C424S229100, C424S230100, C424S231100, C424S093200, C424S093210, C424S278100, C424S205100, C435S355000, C435S372000, C435S325000, C435S235100, C435S320100

Reexamination Certificate

active

07063851

ABSTRACT:
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:(i) lacks a functional vhs gene, or a functional equivalent thereof;(ii) lacks a functional ICP47 gene, or a functional equivalent thereof; and(iii) is incapable of expressing a substantial amount of functional ICP22, or a functional equivalent thereof, in mammalian dendritic cells.

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