Herpes virus complementing cell line

Details Herpes virus complementing cell line Herpes virus complementing cell line

2005-01-11

2005-01-11

Scheiner, Laurie (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S236000, C435S325000, C435S364000, C424S205100, C424S231100, C424S093200

Reexamination Certificate

active

06841373

ABSTRACT:
The present invention is directed to a cell line capable of supporting replication of a growth-defective Herpes Simplex Virus strain; specifically a replication-defective HSV-2 double mutant. Particularly disclosed is a cell line that expresses the ICP8 protein and the UL5 protein of Herpes Simplex Virus. This cell line is useful to propagate a replication-defective HSV-2 vaccine strain that contains mutations and/or deletions in the ICP8 and UL5 genes.

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