Herpes simplex virus strains for gene transfer

Details Herpes simplex virus strains for gene transfer Herpes simplex virus strains for gene transfer

1995-06-07

1999-03-09

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

536 2372, C12N 1586

Patent

active

058799346

ABSTRACT:
Cell lines that express complementing levels of herpes simplex virus (HSV) essential immediate early proteins ICP4 and ICP27 and a method of producing the novel cell lines are disclosed. These cell lines are utilized to provide HSV strains deficient for both ICP4 and ICP27, and their generation, and HSV strains deficient for ICP4 and ICP27 and one or more additional genes, and their generation. Vectors are provided from these methods of using these HSV strains for gene transfer and for producing site-specific homologous recombination with cellular DNA.

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