Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-05-22
1998-09-08
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4352351, 4353201, 435364, C12N 506, C12N 704, C12N 1509, C12N 1586
Patent
active
058044132
ABSTRACT:
Cell lines that express complementing levels of herpes simplex virus (HSV) essential immediate early proteins ICP4 and ICP27 as well as ICP4, ICP27 and ICP0 and a method of producing the novel cell lines are disclosed. These cell lines are utilized to provide HSV strains deficient for both (a) ICP4 and ICP27; (b) ICP4, ICP27, ICP22; (c) ICP4, ICP27, ICP0; and, (d) ICP4, ICP27, ICP22 and ICP0, and their generation, and HSV strains deficient for (a) ICP4 and ICP27; (b) ICP4, ICP27, ICP22; (c) ICP4, ICP27, ICP0; and, (d) ICP4, ICP27, ICP22 and ICP0, and one or more additional genes, and their generation. Vectors are provided from these methods of using these HSV strains for gene transfer and for producing site-specific homologous recombination with cellular DNA.
REFERENCES:
patent: 5026635 (1991-06-01), Ferguson et al.
patent: 5070010 (1991-12-01), Hsu
patent: 5124263 (1992-06-01), Temin et al.
patent: 5672344 (1997-09-01), Kelley et al.
patent: 5674722 (1997-10-01), Mulligan et al.
Orkin et al. (Dec. 1995) Report and recommendations of the panel to assess he NIH investment in research on gene therapy, pp. 1-41.
Glorioso et al. (1992) Herpes simplex virus-based vectors. Seminars Virol. 3:265-276.
Brakefield & DeLuca, in: Treatment of Genetic Diseases (Desnick, ed.), 287-319, Churchill Livingstone (1991).
Brakefield and DeLuca, The New Biologist, 3(3), 203-18 (1991).
Chiocca et al., The New Biologist, 2(8), 739-46 (1990).
DeLuca & Schafer, Nucl. Acids Res., 15(11), 4491-4511 (1987).
DeLuca & Schafer, J. Virol., 62, 732-43 (1988).
DeLuca et al., J. Virol., 56, 558-70 (1985).
Imbalzano et al., J. Virol., 565-74 (1991).
Johnson et al., J. Virol., 68(10), 6347-62 (1994).
Kmetz et al., Nucl. Acids Res., 16(10), 4735 (1988).
McCarthy et al., J. Virol., 63, 18-27 (1989).
Paterson & Everett, Nucl. Acids Res., 16(23), 11005-25 (1988).
Paterson & Everett, Virol., 166, 186 (1988).
Shepard et al., J. Virol. 63, 3714-28 (1989).
Shepard et al., J. Viro., 65, 787-95 (1991).
Shih et al., Proc. Natl. Acad. Sci. USA, 81, 5867-70 (1984).
Westruck et al., J. Virol., 64(3), 984-91 (1990).
Elliott George C.
Schwartzman Robert
University of Pittsburgh of the Commonwealth System of Higher Ed
LandOfFree
Herpes simplex virus strains for gene transfer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Herpes simplex virus strains for gene transfer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Herpes simplex virus strains for gene transfer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1281177