Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-08-30
1998-12-08
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4241841, 4242311, 435 5, 536 2372, 536 245, A01N 4306, A61K 39245, C07H 2104, C12Q 168
Patent
active
058469486
ABSTRACT:
The present invention is directed to methods and compositions relating to the treatment of herpes simplex virus infections and the screening of compounds for activity that inhibit or promoter viral latency. The previously identified ORF P gene product now has been shown to interact with certain eukaryotic splicing factors and, in a cell infected with a herpesvirus containing a derepressed ORF P gene, ORF P can limit the splicing of at least two viral products. Given this function, it now is possible to screen for inhibitors and inducers of ORF P and, further, provide methods for maintaining and preventing viral latency.
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Bruni Renato
Roizman Bernard
Achutamurthy Ponnathapura
ARCH Development Corporation
Bui Phuong T.
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