Herpes simplex virus mutant UL41NHB

Details Herpes simplex virus mutant UL41NHB Herpes simplex virus mutant UL41NHB

1995-02-09

1997-12-16

Elliott, George C.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4352351, 435948, C12N 704, C12N 701

Patent

active

056984316

ABSTRACT:
A herpes simplex virus (HSV) mutant, UL41NHB, is disclosed which is deficient in the virion host shutoff (vhs) function. This mutant is shown to be profoundly attenuated in its ability to replicate at the periphery and in the nervous system, and in its ability to reactivate from latency.

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