Herpes simplex virus drug screen

Details Herpes simplex virus drug screen Herpes simplex virus drug screen

1995-02-24

1996-12-17

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, C12Q 168, G01N 3353

Patent

active

055852394

ABSTRACT:
Host Cell Factor (HCF), a eukaryotic cellular protein involved in transcription, nucleic acids encoding HCF, and methods of using HCF and HCF-encoding nucleic acids are provided. HCF activity is disclosed to comprise a collection of polypeptides encoded by a structural gene encoding a parent protein of 2039 amino acids. HCF-specific binding compounds are disclosed including antibodies to HCF epitopes. Because HCF is required for the transcription of a number of viral genes such as the immediate early genes of Herpes Simplex Virus, the invention provides HCF-based pharmaceutical compositions and HCF-based methods for screening chemical libraries for regulators of viral transcription. Such compositions are used in the treatment of viral infections by modulating the transcription of certain viral genes.

REFERENCES:
Xiao et al., Molecular and Cellular Biology, Sep. 1990, vol. 10, No. 9: pp. 4974-4977.
Haigh et al., Nature, Mar. 15, 1990, vol. 344: pp. 257-259.

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