Herpes simplex virus-1 deletion variants and vaccines thereof

Details Herpes simplex virus-1 deletion variants and vaccines thereof Herpes simplex virus-1 deletion variants and vaccines thereof

1996-12-13

2000-03-21

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4352351, C12N 704

Patent

active

060401699

ABSTRACT:
Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of R.sub.L are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a ts mutation into the UL26 gene.

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