Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-02-09
2000-10-24
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4352523, 435325, 514 2, 530300, 530350, 536 231, C12P 2106
Patent
active
061365580
ABSTRACT:
The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-.beta.1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
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Ballinger Marcus D.
Fairbrother Wayne J.
Jones Jennifer T.
Sliwkowski Mark X.
Wells James A.
Genentech Inc.
Haliday Emily M.
Kemmerer Elizabeth
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