Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from leguminosae
Reexamination Certificate
2007-10-02
2007-10-02
Flood, Michele (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from leguminosae
C514S025000, C514S866000
Reexamination Certificate
active
10809645
ABSTRACT:
The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA4), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.
REFERENCES:
patent: 5773004 (1998-06-01), Takahashi
Davies M J et al., Diabetic Medicine (May 2004), 21(5): 403-414. Prevention of Type 2 diabetes mellitus. A review of the evidence and its application in a UK setting.
Sturis, J et al., American J of Physiology (1995), 269(4Pt 1): E786-92. Prevention of diabetes does not completely prevent insulin secretion defects in the ZDF rat.
Shukla, S. International Journal of Pharmacognosy (1995), 33(4): 324-3293 Toxicology studies ofPueraria tuberosa, a potent antifertility plant. Abstract.
Friedman, J. E. et al. American Journal of Physiology (1991), 261(6): 74-80. Altered expression of muscle glucose transporter GLUT-4 in diabetic fatty Zucker rats (ZDF/Drt-fa).
Bandopadhyay Santu
Bandyopadhyay Arun
Bhattacharya Samir
Biswas Tanushree
Chandra Pal Bikash
Council of Scientific & Industrial Research
Flood Michele
Madan Mossman & Sriram P.C.
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