Herbal composition

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...

Reexamination Certificate

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Reexamination Certificate

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07862837

ABSTRACT:
The present invention relates to a novel herbal composition comprising extract of leaves ofPolyalthia longifoliaand method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16-hydroxycleroda-3,13(14)-dien-15,16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.

REFERENCES:
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Zhao, G. “Cytotoxic Clerodane Diterpenes fromPolyalthia longifolia” Planta Med. vol. 57. 1991. pp. 380-383.
Ramakrishna. N., et al. “Screening of natural products for new leads as inhibitors of lκBα kinase: 16-Oxo-cleroda-3. 13E-dien-15-oic acid fromPolyalthia longifoliaofAnnonaceaefamily”, Indian Journal of Chemistry. vol. 39B, Oct. 2000, pp. 801-802.
Murthy, M. et al. “Antimicrobial activity of clerodane diterpenoids fromPolyalthia longifoliaseeds”, Fitoterapia, vol. 76, 2005, pp. 336-339.
Hara, N. et al., “Clerodane andENT-Halimane Diterpenes fromPolyalthfa longifolia”, Phytochemistry, vol. 38, No. 1, 1995, pp. 189-194.
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Imamura, P. et al., “Synthesis of 16, 18-Dihydroxycleroda-3, 13Z.-dien-15, 15-olide, (+)-16-Hydroxycleroda-3, 13Z-dien-16, 15-olide from (+)-Hardwickiic Acid”, Journal of Natural Products, vol. 16, 2000, pp. 1623-1625.
Rashid et al., “Antimicrobial Diterpenes from Polyalthia longifolia var. pendulla (Annonaceae),” Phytotherapy Research, vol. 10, pp. 79-81, 1996.
Hagiwara et al., “A Total Synthesis of Antibacterial Clerodane, 16-Hydroxcleroda-3,13(14)Z-dien-15,16-olide,” Tetrahedron Letters, vol. 35, No. 44, pp. 8189-8192, 1994.
Annapurna et al., “Antimicrobial Activity of Leaf Extracts of Polyalthia longifolia,” Phytopathologische Zeitschrift, vol. 106, pp. 183-185, 1983.
Kuo et al., “Chemical constituents and Their Pharmacological Activities from Formosan Annonaceous Plants,” The Chinese Pharmaceutical Journal, vol. 54, pp. 155-173, 2002.
Saleem et al., “Hypotensive Activity and Toxicology of Constituents from Root Bark of Polyalthia longifolia var. pendula,” Phytotherapy Research, vol. 19, pp. 881-884, 2005.
Chang et al., “Anti-Inflammatory and Cytotoxic Diterpenes from Formosan Polyalthia longifolia var. pendula,” Planta Medica, vol. 72, pp. 1344-1347, 2006.
“Dr. Rathish Nair,” by The Science Advisory Board, located at http://www.scienceboard.net/jobs/resumes.asp?action=details&candidate—id=1863, 7 pages.

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