HER-2 binding antagonists

Details HER-2 binding antagonists HER-2 binding antagonists

2011-05-10

2011-05-10

Harris, Alana M. (Department: 1643)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

C424S001450, C424S001690, C424S185100, C424S193100, C514S002600, C514S012200, C530S395000, C530S402000

Reexamination Certificate

active

07939080

ABSTRACT:
There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO:1, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 108, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO:2, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier.

REFERENCES:
patent: 4376110 (1983-03-01), David et al.
patent: 4777127 (1988-10-01), Suni et al.
patent: 4933294 (1990-06-01), Waterfield et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4959314 (1990-09-01), Mark et al.
patent: 5149655 (1992-09-01), McCabe et al.
patent: 5206152 (1993-04-01), Sukhatme
patent: 5219740 (1993-06-01), Miller et al.
patent: 5401638 (1995-03-01), Carney et al.
patent: 5422120 (1995-06-01), Kim
patent: 5464751 (1995-11-01), Greene et al.
patent: 5514554 (1996-05-01), Bacus
patent: 5571894 (1996-11-01), Wels et al.
patent: 5578482 (1996-11-01), Lippman et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5604107 (1997-02-01), Carney et al.
patent: 5677171 (1997-10-01), Hudziak et al.
patent: 5705157 (1998-01-01), Greene et al.
patent: 5720937 (1998-02-01), Hudziak et al.
patent: 5720954 (1998-02-01), Hudziak et al.
patent: 5747261 (1998-05-01), King et al.
patent: 5756456 (1998-05-01), Ho et al.
patent: 5763213 (1998-06-01), Ho et al.
patent: 5772997 (1998-06-01), Hudziak et al.
patent: 5783186 (1998-07-01), Arakawa et al.
patent: 5811098 (1998-09-01), Plowman et al.
patent: 5814482 (1998-09-01), Dubensky, Jr. et al.
patent: 5837523 (1998-11-01), Greene et al.
patent: 5861301 (1999-01-01), Terman et al.
patent: 5874528 (1999-02-01), Lupu et al.
patent: 5876712 (1999-03-01), Cheever et al.
patent: 5910583 (1999-06-01), Marks et al.
patent: 5919764 (1999-07-01), Greene et al.
patent: 5985553 (1999-11-01), King et al.
patent: 6015567 (2000-01-01), Hudziak et al.
patent: 6020306 (2000-02-01), Boyd et al.
patent: 6045797 (2000-04-01), Margolis et al.
patent: 6054561 (2000-04-01), Ring
patent: 6166082 (2000-12-01), Kluender et al.
patent: 6174889 (2001-01-01), Cockerill et al.
patent: 6204011 (2001-03-01), Kendall et al.
patent: 6267958 (2001-07-01), Andya et al.
patent: 6331526 (2001-12-01), Baserga et al.
patent: 6333169 (2001-12-01), Hudziak et al.
patent: 6337338 (2002-01-01), Kozlowski et al.
patent: 6340674 (2002-01-01), Baserga et al.
patent: 6359115 (2002-03-01), Kendall et al.
patent: 6375929 (2002-04-01), Thomas, Jr. et al.
patent: 6387371 (2002-05-01), Hudziak et al.
patent: 6399063 (2002-06-01), Hudziak et al.
patent: 6399743 (2002-06-01), Majumdar
patent: 6414130 (2002-07-01), Doherty et al.
patent: 6417168 (2002-07-01), Greene et al.
patent: 6441143 (2002-08-01), Koski
patent: 6541214 (2003-04-01), Clinton
patent: 6582934 (2003-06-01), Majumdar
patent: 6673343 (2004-01-01), Bennett et al.
patent: 6685940 (2004-02-01), Andya et al.
patent: 6696548 (2004-02-01), Morris et al.
patent: 6841367 (2005-01-01), Kendall et al.
patent: 6969596 (2005-11-01), Ghildyal et al.
patent: 7125680 (2006-10-01), Singer et al.
patent: 7125959 (2006-10-01), Desnoyers et al.
patent: 7153941 (2006-12-01), Goddard et al.
patent: 2002/0064785 (2002-05-01), Mass
patent: 2002/0146420 (2002-10-01), Bennett et al.
patent: 2002/0155527 (2002-10-01), Stuart et al.
patent: 2002/0165193 (2002-11-01), Greene et al.
patent: 2002/0172984 (2002-11-01), Holland et al.
patent: 2002/0173458 (2002-11-01), Ruben et al.
patent: 2003/0036179 (2003-02-01), Baker et al.
patent: 2003/0055239 (2003-03-01), Kendall et al.
patent: 2003/0059863 (2003-03-01), Clinton
patent: 2003/0105051 (2003-06-01), McSwiggen
patent: 2003/0157097 (2003-08-01), Noguchi et al.
patent: 2003/0171278 (2003-09-01), Dennis
patent: 2003/0228663 (2003-12-01), Lowman et al.
patent: 2003/0235556 (2003-12-01), Wolin et al.
patent: 2004/0022785 (2004-02-01), Clinton et al.
patent: 2004/0023887 (2004-02-01), Pillutla et al.
patent: 2004/0052796 (2004-03-01), Clinton
patent: 2004/0082510 (2004-04-01), Ullrich et al.
patent: 2004/0106161 (2004-06-01), Bossenmaier et al.
patent: 2004/0142931 (2004-07-01), Vite et al.
patent: 2004/0242684 (2004-12-01), Chen et al.
patent: 2005/0239088 (2005-10-01), Shepard et al.
patent: B-64135/90 (1991-03-01), None
patent: 777422 (2004-10-01), None
patent: 777803 (2004-10-01), None
patent: 2042064 (1991-02-01), None
patent: 2187781 (1995-09-01), None
patent: 2260061 (1998-01-01), None
patent: 2418083 (2002-02-01), None
patent: 2055441 (2003-07-01), None
patent: 1607247 (2005-04-01), None
patent: 0119528 (1984-09-01), None
patent: 0171407 (1986-02-01), None
patent: 0345242 (1989-12-01), None
patent: 0412116 (1991-02-01), None
patent: 0444181 (1991-09-01), None
patent: 0474727 (1992-03-01), None
patent: 0491675 (1992-06-01), None
patent: 0494135 (1992-07-01), None
patent: 0524968 (1993-02-01), None
patent: 0600744 (1994-06-01), None
patent: 1006194 (2000-06-01), None
patent: 1114863 (2001-07-01), None
patent: 1304110 (2003-04-01), None
patent: 1308455 (2003-05-01), None
patent: 2200651 (1988-08-01), None
patent: WO 85/03357 (1985-08-01), None
patent: WO 89/10412 (1989-11-01), None
patent: WO 90/07936 (1990-07-01), None
patent: WO 90/11092 (1990-10-01), None
patent: WO 90/14357 (1990-11-01), None
patent: WO 91/02062 (1991-02-01), None
patent: WO 91/02805 (1991-03-01), None
patent: WO 91/05264 (1991-04-01), None
patent: WO 91/11715 (1991-08-01), None
patent: WO 91/14445 (1991-10-01), None
patent: WO 92/11033 (1992-07-01), None
patent: WO 92/14748 (1992-09-01), None
patent: WO 92/20798 (1992-11-01), None
patent: WO 93/03769 (1993-03-01), None
patent: WO 93/10218 (1993-05-01), None
patent: WO 93/11230 (1993-06-01), None
patent: WO 93/14124 (1993-07-01), None
patent: WO 93/14778 (1993-08-01), None
patent: WO 93/19191 (1993-09-01), None
patent: WO 93/25234 (1993-12-01), None
patent: WO 93/25698 (1993-12-01), None
patent: WO 94/03622 (1994-02-01), None
patent: WO 94/12649 (1994-06-01), None
patent: WO 94/23697 (1994-10-01), None
patent: WO 94/28938 (1994-12-01), None
patent: WO 95/00655 (1995-01-01), None
patent: WO 95/07994 (1995-03-01), None
patent: WO 95/11984 (1995-05-01), None
patent: WO 95/13796 (1995-05-01), None
patent: WO 95/25166 (1995-09-01), None
patent: WO 95/30331 (1995-11-01), None
patent: WO 95/30763 (1995-11-01), None
patent: WO 96/17072 (1996-06-01), None
patent: WO 97/18241 (1997-05-01), None
patent: WO 97/42338 (1997-11-01), None
patent: WO 98/02438 (1998-01-01), None
patent: WO 98/23782 (1998-06-01), None
patent: WO 99/19732 (1999-04-01), None
patent: WO 99/39729 (1999-08-01), None
patent: WO 00/27426 (2000-05-01), None
patent: WO 00/29609 (2000-05-01), None
patent: WO 00/35455 (2000-06-01), None
patent: WO 00/44403 (2000-08-01), None
patent: WO 01/01748 (2001-01-01), None
patent: WO 01/26607 (2001-04-01), None
patent: WO 01/61356 (2001-08-01), None
patent: WO 01/89566 (2001-11-01), None
patent: WO 02/11677 (2002-02-01), None
patent: WO 02/12335 (2002-02-01), None
patent: WO 02/14470 (2002-02-01), None
patent: WO 02/90991 (2002-11-01), None
patent: WO 03/025141 (2003-03-01), None
patent: WO 03/035843 (2003-05-01), None
patent: WO 03/060071 (2003-07-01), None
patent: WO 03/061571 (2003-07-01), None
patent: WO 03/070747 (2003-08-01), None
patent: WO 2004/041065 (2004-05-01), None
patent: WO 2004/054996 (2004-07-01), None
patent: WO 2004/055022 (2004-07-01), None
patent: WO 2005/016966 (2005-02-01), None
patent: WO 2005/112969 (2005-12-01), None
patent: WO 2006/042002 (2006-04-01), None
Adachi et al., “Effects of Genetic Blockage of the Insulin-like Growth Factor Receptor in Human Colon Cancer Cell Lines,” Gastroenterology 123(4):1191-1204, Oct. 2002.
A

Affiliated with

Also associated with

Rating

HER-2 binding antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HER-2 binding antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HER-2 binding antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2703949