Heptitols

Details Heptitols Heptitols

1994-01-18

1995-01-24

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30720

Patent

active

053844173

ABSTRACT:
Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.

REFERENCES:
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patent: 5136036 (1992-08-01), Fleet et al.
Myerscough, Tetrahedron 48 (46) 16, 177 (1992).
Bruce et al., Tetrahedrom 46 (1), 19-32 (1990).
Beacham et al., Tetrahedrom:Asymmetry 2 (9), 883-900 (1991).
Cenci Di Bello et al., Biochem. J. 259, 855-861 (1989).
Carpenter et al., Tetrahedron Lett. 30 (51), 7261-7264 (1989).
Choi et al., Tetrahedron Lett. 32 (40), 5517-5520 (1991).

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