Heptenoic acid derivatives

Details Heptenoic acid derivatives Heptenoic acid derivatives

1984-06-04

1986-05-13

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

549214, 549292, 556441, C07F 708, A61K 31695

Patent

active

045887152

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation; or a -6-oxotetrahydropyran-2-yl ring of the formula Z": ##STR3## e.g. 4-hydroxy-6-{2-[2-(methyldiphenylsilyl)phenyl]ethenyl]ethyenyl}-tetrahydro -2H-pyran-2-one, (trans, trans). The compounds inhibit cholesterol biosynthesis and are useful as anti-atherosclerotic agents.

REFERENCES:
patent: 4000265 (1976-12-01), Quilichini
patent: 4255444 (1981-03-01), Oka et al.
patent: 4262013 (1981-04-01), Mistui et al.
patent: 4293496 (1981-10-01), Willard
patent: 4361515 (1982-11-01), Terahara et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4420475 (1983-12-01), Damon, II
patent: 4472426 (1984-09-01), Hoffman et al.

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