Heptadecapeptide

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07C10352

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active

044811381

ABSTRACT:
A substance having opiate and analgesic activity is obtained from swine duodenum. The opioid substance of the present invention comprises a heptadecapeptide having the following primary amino acid structure: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln.

REFERENCES:
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patent: 4117117 (1978-09-01), Wunsch
patent: 4172130 (1979-10-01), Kisfaludy et al.
Beaumont and Hughes, Biology of Opioid Peptides, Ann. Rev. Pharmacol. Toxicol. 1979, 19:245-267.
The Merck Index, Ninth Edition, 1976, pp. 283 and 1091.
Chikara Oyama: Shindan to Chiryo (Diagnosis and Therapy) 68, pp. 825-827 (1980).
Tampakushitsu, Kakusan, Koso (Protein, Nucleic Acid and Enzyme), vol. 26, No. 2, pp. 1-36 (1981).
Suzuki, Araki and Tachibana: Yakugaku-Zasshi 99, pp. 172-179 (1979).

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